In order to elucidate the factors related to the development of cidofovir-associated uveitis in AIDS patients receiving highly active antiretroviral therapy, the characteristics of 17 AIDS patients with Cytomegalovirus retinitis ( n=10) or progressive multifocal leukoencephalopathy ( n=7) treated with intravenous cidofovir were evaluated. Six cases of cidofovir-associated uveitis occurred among the patients with retinitis. No cases were detected among the patients with progressive multifocal leukoencephalopathy. Stepwise linear regression analysis revealed a significantly higher HIV-viremia level ( P=0.01) and a significantly lower CD4+ cell count ( P=0.009) among cases at the time of uveitis onset in comparison with patients who did not develop uveitis. Thus, cidofovir-associated uveitis seems to occur more frequently in AIDS patients with retinitis in whom highly active antiretroviral therapy fails to restore immunity.

Tacconelli, E., Tumbarello, M., Rabagliati, R., Scoppettuolo, G., Minnella, A. M., Ventura, G., Cauda, R., Correlation between cidofovir-associated uveitis and failing immunorestoration during HAART., <<EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES>>, 2003; (22): 114-117 [http://hdl.handle.net/10807/12779]

Correlation between cidofovir-associated uveitis and failing immunorestoration during HAART.

Tacconelli;Evelina; Tumbarello;Ricardo; Scoppettuolo;Giancarlo; Minnella;Angelo Maria; Ventura;Giulio; Cauda
2003

Abstract

In order to elucidate the factors related to the development of cidofovir-associated uveitis in AIDS patients receiving highly active antiretroviral therapy, the characteristics of 17 AIDS patients with Cytomegalovirus retinitis ( n=10) or progressive multifocal leukoencephalopathy ( n=7) treated with intravenous cidofovir were evaluated. Six cases of cidofovir-associated uveitis occurred among the patients with retinitis. No cases were detected among the patients with progressive multifocal leukoencephalopathy. Stepwise linear regression analysis revealed a significantly higher HIV-viremia level ( P=0.01) and a significantly lower CD4+ cell count ( P=0.009) among cases at the time of uveitis onset in comparison with patients who did not develop uveitis. Thus, cidofovir-associated uveitis seems to occur more frequently in AIDS patients with retinitis in whom highly active antiretroviral therapy fails to restore immunity.
Inglese
Tacconelli, E., Tumbarello, M., Rabagliati, R., Scoppettuolo, G., Minnella, A. M., Ventura, G., Cauda, R., Correlation between cidofovir-associated uveitis and failing immunorestoration during HAART., <<EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES>>, 2003; (22): 114-117 [http://hdl.handle.net/10807/12779]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/12779
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