The aim of this study was to evaluate the effect of highly active antiretroviral therapy (HAART) on the incidence of bacterial infections in HIV-infected patients. Two time periods were compared: (A) January 1992-December 1995 (before HAART) and (B) January 1997-December 2000 (after HAART). During the study periods, we observed 931 patients with bacterial infections, i.e. 322 with bacteremia, 369 with bacterial pneumonia and 240 with urinary tract infections, out of 4,242 HIV-infected subjects admitted to the Department of Infectious Diseases of a large university hospital. By comparing the overall incidence of bacterial infections during periods A and B, a statistically significant difference, from 32% to 18% (p<0.01), was observed. Analysis of risk factors of community- and hospital-acquired bacterial infections did not significantly differ in the two study periods. This study establishes that a significant reduction in bacterial infection incidence occurred in HIV-infected subjects when HAART became the standard therapy for HIV infection.

De Gaetano Donati, K., Tumbarello, M., Tacconelli, E., Bertagnolio, S., Rabagliati, R., Scoppettuolo, G., Citton, R., Cataldo, M., Rastrelli, E., Fadda, G., Cauda, R., Impact of highly active antiretroviral therapy (HAART) on the incidence of bacterial infections in HIV infected subjects, <<JOURNAL OF CHEMOTHERAPY>>, 2003; 2003 (15): 60-65 [http://hdl.handle.net/10807/12777]

Impact of highly active antiretroviral therapy (HAART) on the incidence of bacterial infections in HIV infected subjects

De Gaetano Donati, Katleen;Tumbarello, Mario;Tacconelli, Evelina;Bertagnolio, Silvia;Scoppettuolo, Giancarlo;Citton, Rita;Cataldo, Maria;Rastrelli, Elena;Fadda, Giovanni;Cauda, Roberto
2003

Abstract

The aim of this study was to evaluate the effect of highly active antiretroviral therapy (HAART) on the incidence of bacterial infections in HIV-infected patients. Two time periods were compared: (A) January 1992-December 1995 (before HAART) and (B) January 1997-December 2000 (after HAART). During the study periods, we observed 931 patients with bacterial infections, i.e. 322 with bacteremia, 369 with bacterial pneumonia and 240 with urinary tract infections, out of 4,242 HIV-infected subjects admitted to the Department of Infectious Diseases of a large university hospital. By comparing the overall incidence of bacterial infections during periods A and B, a statistically significant difference, from 32% to 18% (p<0.01), was observed. Analysis of risk factors of community- and hospital-acquired bacterial infections did not significantly differ in the two study periods. This study establishes that a significant reduction in bacterial infection incidence occurred in HIV-infected subjects when HAART became the standard therapy for HIV infection.
Inglese
De Gaetano Donati, K., Tumbarello, M., Tacconelli, E., Bertagnolio, S., Rabagliati, R., Scoppettuolo, G., Citton, R., Cataldo, M., Rastrelli, E., Fadda, G., Cauda, R., Impact of highly active antiretroviral therapy (HAART) on the incidence of bacterial infections in HIV infected subjects, <>, 2003; 2003 (15): 60-65 [http://hdl.handle.net/10807/12777]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/12777
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact