AIMS AND BACKGROUND: Retroperitoneal sarcomas are a rare group of malignant soft tissue tumors with a generally poor prognosis. The aim of the study was to assess clinical, pathological and treatment-related factors affecting prognosis in patients with retroperitoneal sarcomas. METHODS AND STUDY DESIGN: The hospital records of 73 patients who underwent surgical exploration at our unit for primary retroperitoneal sarcomas between 1984 and 2003 were reviewed. Factors influencing overall and disease-free survival were analyzed for all patients and for those who underwent complete surgical resection. RESULTS: The complete resectability rate was 69.8% (51/73). Operative mortality and morbidity rates were 2.7% and 21.9%, respectively. For patients who underwent complete resection, the 5-year survival rate was 58.3%, whereas it was 0% in cases of incomplete or no resection (P < 0.001). Local recurrence rate was 37.2%. Incomplete gross surgical resection and microscopic infiltration of margins were the most important independent predictors of a poor prognosis. CONCLUSIONS: The present study confirmed the importance of an aggressive surgical management for retroperitoneal sarcomas to offer these patients the best chance for long-term survival.

Pacelli, F., Tortorelli, A. P., Rosa, F., Papa, V., Bossola, M., Sanchez, A. M., Ferro, A., Menghi, R., Covino, M., Doglietto, G., Retroperitoneal soft tissue sarcoma: prognostic factors and therapeutic approaches, <<TUMORI>>, 2008; (Luglio): 497-504 [http://hdl.handle.net/10807/12739]

Retroperitoneal soft tissue sarcoma: prognostic factors and therapeutic approaches

Pacelli, Fabio;Tortorelli, Antonio Pio;Rosa, Fausto;Papa, Valerio;Bossola, Maurizio;Sanchez, Alejandro Martin;Menghi, Roberta;Covino, Marcello;Doglietto, Giovanni
2008

Abstract

AIMS AND BACKGROUND: Retroperitoneal sarcomas are a rare group of malignant soft tissue tumors with a generally poor prognosis. The aim of the study was to assess clinical, pathological and treatment-related factors affecting prognosis in patients with retroperitoneal sarcomas. METHODS AND STUDY DESIGN: The hospital records of 73 patients who underwent surgical exploration at our unit for primary retroperitoneal sarcomas between 1984 and 2003 were reviewed. Factors influencing overall and disease-free survival were analyzed for all patients and for those who underwent complete surgical resection. RESULTS: The complete resectability rate was 69.8% (51/73). Operative mortality and morbidity rates were 2.7% and 21.9%, respectively. For patients who underwent complete resection, the 5-year survival rate was 58.3%, whereas it was 0% in cases of incomplete or no resection (P < 0.001). Local recurrence rate was 37.2%. Incomplete gross surgical resection and microscopic infiltration of margins were the most important independent predictors of a poor prognosis. CONCLUSIONS: The present study confirmed the importance of an aggressive surgical management for retroperitoneal sarcomas to offer these patients the best chance for long-term survival.
Inglese
Pacelli, F., Tortorelli, A. P., Rosa, F., Papa, V., Bossola, M., Sanchez, A. M., Ferro, A., Menghi, R., Covino, M., Doglietto, G., Retroperitoneal soft tissue sarcoma: prognostic factors and therapeutic approaches, <<TUMORI>>, 2008; (Luglio): 497-504 [http://hdl.handle.net/10807/12739]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/12739
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