A prospective, randomised, double-blind study was conducted to compare the efficacy of two doses of levobupivacaine combined with sufentanil for continuous epidural infusion following thoractomy. A total of 72 patients undergoing lobectomy or pneumonectomy were enrolled. An epidural catheter was inserted between the levels of T4 and T6 before induction of anaesthesia and a loading dose of levobupivacaine and sufentanil was administered. At the end of surgery an epidural infusion was commenced at 5 mlxh(-1) and continued for 48 h. Patients were randomly allocated to receive either levobupivacaine 0.125% (group A) or 0.0625% (group B) and all patients also received sufentanil (1 microgxml(-1)). Visual analogue pain scores after coughing (VASi) were always higher in group B (p < 0.05); VAS pain scores at rest were higher for the first 4 h and at 16 and 28 h in group B (p < 0.05). Total morphine consumption and requests number was lower in group A (p < 0.05). Better pain relief was achieved using epidural 0.125% levobupivacaine.

De Cosmo, G., Congedo, E., Mascia, A., Adducci, E., Lai, C., Aceto, P., Epidural infusion of levobupivacaine and sufentanil following thoracotomy, <<ANAESTHESIA>>, 2007; 2007 (Ottobre): 994-999. [doi:10.1111/j.1365-2044.2007.05184.x] [http://hdl.handle.net/10807/123644]

Epidural infusion of levobupivacaine and sufentanil following thoracotomy

De Cosmo, Germano;Congedo, Elisabetta;Mascia, Antonio;Adducci, Enrica;Lai, Carlo;Aceto, Paola
2007

Abstract

A prospective, randomised, double-blind study was conducted to compare the efficacy of two doses of levobupivacaine combined with sufentanil for continuous epidural infusion following thoractomy. A total of 72 patients undergoing lobectomy or pneumonectomy were enrolled. An epidural catheter was inserted between the levels of T4 and T6 before induction of anaesthesia and a loading dose of levobupivacaine and sufentanil was administered. At the end of surgery an epidural infusion was commenced at 5 mlxh(-1) and continued for 48 h. Patients were randomly allocated to receive either levobupivacaine 0.125% (group A) or 0.0625% (group B) and all patients also received sufentanil (1 microgxml(-1)). Visual analogue pain scores after coughing (VASi) were always higher in group B (p < 0.05); VAS pain scores at rest were higher for the first 4 h and at 16 and 28 h in group B (p < 0.05). Total morphine consumption and requests number was lower in group A (p < 0.05). Better pain relief was achieved using epidural 0.125% levobupivacaine.
Inglese
De Cosmo, G., Congedo, E., Mascia, A., Adducci, E., Lai, C., Aceto, P., Epidural infusion of levobupivacaine and sufentanil following thoracotomy, <<ANAESTHESIA>>, 2007; 2007 (Ottobre): 994-999. [doi:10.1111/j.1365-2044.2007.05184.x] [http://hdl.handle.net/10807/123644]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/123644
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