Objective: Despite improved outcomes for open repair of descending thoracic aneurysm (DTA) and thoracoabdominal aortic aneurysm (TAAA), these operations remain challenging in octogenarians. Patients unsuitable for thoracic endovascular aortic repair require open surgery to avoid catastrophic rupture. We analyzed our results for DTA/TAAA repair in these elderly patients. Methods: Our institutional aortic database was queried to identify those ≥80 years old and those <80 years old undergoing open DTA/TAAA repair. Logistic and Cox regression analyses were used to account for confounders and to identify predictors of perioperative and long-term outcomes. Results: From 1997 to 2017, there were 783 patients who underwent open repair of DTA or TAAA; 96 (12.3%) were ≥80 years old. Octogenarians were more likely to be female (P =.018), with chronic pulmonary disease (P =.012), severe peripheral vascular disease (P <.001), and hypertension (P =.025). Degenerative aneurysms were more common among octogenarians (P <.001), whereas chronic and acute dissections were more common among those younger than 80 years (P <.001 for both). Operative mortality was 5.6% and was not negatively affected by advanced age (<80 years, 5.7%; ≥80 years, 5.6%; P =.852). Other than an increased incidence of left recurrent nerve palsy in the younger cohort (<80 years, 6.7%; ≥ 80 years, 1.0%; P =.029), there were no significant differences in the incidence of major postoperative complications. Logistic regression modeling showed that age ≥80 years was not predictive of operative mortality or postoperative complications. A greater percentage of octogenarians had aortic reconstruction with a clamp and sew strategy (85.4% vs 61.6%; P <.001), which led to significantly shorter cross-clamp times in this cohort (26.6 minutes vs 30.7 minutes; P <.004). In octogenarians, the incidence of major postoperative adverse events was associated with extent II aneurysms (odds ratio, 2.6; P <.025). Short- and long-term survival was significantly reduced in octogenarians. Conclusions: In select octogenarians, open repair of DTA/TAAA can be performed with acceptable risk. A simplified surgical approach may provide the best opportunity for a successful outcome.

Girardi, L. N., Lau, C., Ohmes, L. B., Degner, B. C., Leonard, J. R., Abouarab, A., Di Franco, A., Iannacone, E. M., Munjal, M., Gaudino, M., Open repair of descending and thoracoabdominal aortic aneurysms in octogenarians, <<JOURNAL OF VASCULAR SURGERY>>, 2018; (18): N/A-N/A. [doi:10.1016/j.jvs.2017.12.083] [http://hdl.handle.net/10807/120735]

Open repair of descending and thoracoabdominal aortic aneurysms in octogenarians

Di Franco, Antonino;Gaudino, Mario
2018

Abstract

Objective: Despite improved outcomes for open repair of descending thoracic aneurysm (DTA) and thoracoabdominal aortic aneurysm (TAAA), these operations remain challenging in octogenarians. Patients unsuitable for thoracic endovascular aortic repair require open surgery to avoid catastrophic rupture. We analyzed our results for DTA/TAAA repair in these elderly patients. Methods: Our institutional aortic database was queried to identify those ≥80 years old and those <80 years old undergoing open DTA/TAAA repair. Logistic and Cox regression analyses were used to account for confounders and to identify predictors of perioperative and long-term outcomes. Results: From 1997 to 2017, there were 783 patients who underwent open repair of DTA or TAAA; 96 (12.3%) were ≥80 years old. Octogenarians were more likely to be female (P =.018), with chronic pulmonary disease (P =.012), severe peripheral vascular disease (P <.001), and hypertension (P =.025). Degenerative aneurysms were more common among octogenarians (P <.001), whereas chronic and acute dissections were more common among those younger than 80 years (P <.001 for both). Operative mortality was 5.6% and was not negatively affected by advanced age (<80 years, 5.7%; ≥80 years, 5.6%; P =.852). Other than an increased incidence of left recurrent nerve palsy in the younger cohort (<80 years, 6.7%; ≥ 80 years, 1.0%; P =.029), there were no significant differences in the incidence of major postoperative complications. Logistic regression modeling showed that age ≥80 years was not predictive of operative mortality or postoperative complications. A greater percentage of octogenarians had aortic reconstruction with a clamp and sew strategy (85.4% vs 61.6%; P <.001), which led to significantly shorter cross-clamp times in this cohort (26.6 minutes vs 30.7 minutes; P <.004). In octogenarians, the incidence of major postoperative adverse events was associated with extent II aneurysms (odds ratio, 2.6; P <.025). Short- and long-term survival was significantly reduced in octogenarians. Conclusions: In select octogenarians, open repair of DTA/TAAA can be performed with acceptable risk. A simplified surgical approach may provide the best opportunity for a successful outcome.
Inglese
Girardi, L. N., Lau, C., Ohmes, L. B., Degner, B. C., Leonard, J. R., Abouarab, A., Di Franco, A., Iannacone, E. M., Munjal, M., Gaudino, M., Open repair of descending and thoracoabdominal aortic aneurysms in octogenarians, <<JOURNAL OF VASCULAR SURGERY>>, 2018; (18): N/A-N/A. [doi:10.1016/j.jvs.2017.12.083] [http://hdl.handle.net/10807/120735]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/120735
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