Novel macrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agents against wild-type and fluconazole resistant Candida species. Macrocyclic compounds 11 and 18 were synthesized through a convergent approach using as a key step a ring-closing metathesis macrocyclization reaction, whereas compounds 25 were obtained by our previously reported synthetic pathway. All the macrocyclic amidinoureas showed antifungal activity toward different Candida species higher or comparable to fluconazole and resulted highly active against fluconazole resistant Candida strains showing in many cases minimum inhibitory concentration values lower than voriconazole. © 2013 American Chemical Society.

Sanguinetti, M., Sanfilippo, S., Castagnolo, D., Sanglard, D., Posteraro, B., Donzellini, G., Botta, M., Novel macrocyclic amidinoureas: Potent non-azole antifungals active against wild-type and resistant Candida species, <<ACS MEDICINAL CHEMISTRY LETTERS>>, 2013; 4 (9): 852-857. [doi:10.1021/ml400187w] [http://hdl.handle.net/10807/98801]

Novel macrocyclic amidinoureas: Potent non-azole antifungals active against wild-type and resistant Candida species

Sanguinetti, Maurizio
Primo
;
Posteraro, Brunella;
2013

Abstract

Novel macrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agents against wild-type and fluconazole resistant Candida species. Macrocyclic compounds 11 and 18 were synthesized through a convergent approach using as a key step a ring-closing metathesis macrocyclization reaction, whereas compounds 25 were obtained by our previously reported synthetic pathway. All the macrocyclic amidinoureas showed antifungal activity toward different Candida species higher or comparable to fluconazole and resulted highly active against fluconazole resistant Candida strains showing in many cases minimum inhibitory concentration values lower than voriconazole. © 2013 American Chemical Society.
Inglese
http://pubs.acs.org/journal/amclct
Sanguinetti, M., Sanfilippo, S., Castagnolo, D., Sanglard, D., Posteraro, B., Donzellini, G., Botta, M., Novel macrocyclic amidinoureas: Potent non-azole antifungals active against wild-type and resistant Candida species, <>, 2013; 4 (9): 852-857. [doi:10.1021/ml400187w] [http://hdl.handle.net/10807/98801]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/98801
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 19
social impact