We tested 59 common and 27 uncommon Aspergillus species isolates for the susceptibility to the mold-active azole antifungal agents, itraconazole, voriconazole, and posaconazole, using the Sensititre method. The overall essential agreement with the CLSI reference method was 96.5% for itraconazole and posaconazole, and 100% for voriconazole. By Sensititre, as well as CLSI, all of 10 A. fumigatus isolates with a cyp51 mutant genotype were classified as being non-wild-type (MIC > ECV) to triazoles.
Mello, E., Posteraro, B., Vella, A., De Carolis, E., Torelli, R., D'Inzeo, T., Verweij, P. E., Sanguinetti, M., Susceptibility Testing of Common and Uncommon Aspergillus Species Against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method, <<ANTIMICROBIAL AGENTS AND CHEMOTHERAPY>>, 2017; 61 (6): 00168-17-N/A. [doi:10.1128/AAC.00168-17] [http://hdl.handle.net/10807/98185]
Susceptibility Testing of Common and Uncommon Aspergillus Species Against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method
Posteraro, BrunellaSecondo
;Vella, Antonietta;De Carolis, Elena;Torelli, Riccardo;D'Inzeo, Tiziana;Sanguinetti, MaurizioUltimo
2017
Abstract
We tested 59 common and 27 uncommon Aspergillus species isolates for the susceptibility to the mold-active azole antifungal agents, itraconazole, voriconazole, and posaconazole, using the Sensititre method. The overall essential agreement with the CLSI reference method was 96.5% for itraconazole and posaconazole, and 100% for voriconazole. By Sensititre, as well as CLSI, all of 10 A. fumigatus isolates with a cyp51 mutant genotype were classified as being non-wild-type (MIC > ECV) to triazoles.
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