An increased white blood cell count is a hallmark of active Kawasaki syndrome (KS) and has been suggested as a risk factor for cardiovascular morbidity by several investigators. Morphologic analysis of polymorphonuclear cells (PMNs) represents an accessible tool that is worth validating prospectively in a larger study to predict KS severity and poor response to intravenous immunoglobulin. More precisely, PMNs might be culprits in the development of KS and its complications, but they are not the only cells involved in this systemic vasculitis: further in-depth analysis will probably unravel the tangled pathogenesis of KS and find new targets for a more specific therapy.

Andreozzi, L., Bracci, B., D’Errico, F., Rigante, D., A master role for neutrophils in Kawasaki syndrome, <<IMMUNOLOGY LETTERS>>, 2017; 2017 (181): 1-5. [doi:10.1016/j.imlet.2017.02.011] [http://hdl.handle.net/10807/96235]

A master role for neutrophils in Kawasaki syndrome

Rigante, Donato
Ultimo
2017

Abstract

An increased white blood cell count is a hallmark of active Kawasaki syndrome (KS) and has been suggested as a risk factor for cardiovascular morbidity by several investigators. Morphologic analysis of polymorphonuclear cells (PMNs) represents an accessible tool that is worth validating prospectively in a larger study to predict KS severity and poor response to intravenous immunoglobulin. More precisely, PMNs might be culprits in the development of KS and its complications, but they are not the only cells involved in this systemic vasculitis: further in-depth analysis will probably unravel the tangled pathogenesis of KS and find new targets for a more specific therapy.
Inglese
Andreozzi, L., Bracci, B., D’Errico, F., Rigante, D., A master role for neutrophils in Kawasaki syndrome, <<IMMUNOLOGY LETTERS>>, 2017; 2017 (181): 1-5. [doi:10.1016/j.imlet.2017.02.011] [http://hdl.handle.net/10807/96235]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/96235
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 11
social impact