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EnglishInvestigation of membrane fluidity by two photon fluorescence microscopy opens up a new and important area of translational research, being a useful and sensitive method for disease monitoring and treatment. In this paper we investigate if biomembranes in human red blood cells (RBC) and peripheral mononuclear cells (PMC) could be used as markers for type 1 diabetes mellitus (T1DM) diagnosis, leading to the development of a method for monitoring T1DM progression that nowadays is lacking, as clinical exams cannot pursue this task with enough reliability. To this aim, we present a set of features computed from PMC and RBC images that are given to a multi-experts system leveraging on multi-spectral information for positive/negative classifications. The experiments are carried out on a dataset of 800 blood cell images belonging to 18 subjects adopting the leave-one-person-out approach.
Cordelli, E., Pani, G., Pitocco, D., Maulucci, G., Soda, P., Early experiences in using blood cells biomembranes as markers for diabetes diagnosis, Paper (Trinity College Health Sciences Building at St. James's Hospital, irl, 20-23 June 2016), <<PROCEEDINGS - IEEE SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS>>, 2016; 2016- (2016): 197-202.[doi: 10.1109/CBMS.2016.60] [http://hdl.handle.net/10807/96164]
| Autori: | |
| Titolo: | Early experiences in using blood cells biomembranes as markers for diabetes diagnosis |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1109/CBMS.2016.60 |
| Abstract: | Investigation of membrane fluidity by two photon fluorescence microscopy opens up a new and important area of translational research, being a useful and sensitive method for disease monitoring and treatment. In this paper we investigate if biomembranes in human red blood cells (RBC) and peripheral mononuclear cells (PMC) could be used as markers for type 1 diabetes mellitus (T1DM) diagnosis, leading to the development of a method for monitoring T1DM progression that nowadays is lacking, as clinical exams cannot pursue this task with enough reliability. To this aim, we present a set of features computed from PMC and RBC images that are given to a multi-experts system leveraging on multi-spectral information for positive/negative classifications. The experiments are carried out on a dataset of 800 blood cell images belonging to 18 subjects adopting the leave-one-person-out approach. |
| Rivista: | |
| Lingua: | Inglese |
| Nome del convegno: | 29th IEEE International Symposium on Computer-Based Medical Systems, CBMS 2016 |
| Luogo del convegno: | Trinity College Health Sciences Building at St. James's Hospital, irl |
| Data inizio evento: | 2016-06-20 |
| Data fine evento: | 2016-06-23 |
| Tipo di contributo: | Paper |
| Citazione: | Cordelli, E., Pani, G., Pitocco, D., Maulucci, G., Soda, P., Early experiences in using blood cells biomembranes as markers for diabetes diagnosis, Paper (Trinity College Health Sciences Building at St. James's Hospital, irl, 20-23 June 2016), <<PROCEEDINGS - IEEE SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS>>, 2016; 2016- (2016): 197-202.[doi: 10.1109/CBMS.2016.60] [http://hdl.handle.net/10807/96164] |
| Appare nelle tipologie: | Paper, Selected paper, Contributed paper, Working paper, Poster, Poster paper, Comunicazione, Relazione (su rivista) |
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