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EnglishOncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are pre sented and discussed with revision of the pertinent literature.
| Autori: | |
| Titolo: | Oncocytic variant of medullary thyroid carcinoma: a rare case of sporadic multifocal and bilateral RET wild-type neoplasm with revision of the literature |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.4081/rt.2016.6537 |
| Data di pubblicazione: | 2016 |
| Abstract: | Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are pre sented and discussed with revision of the pertinent literature. |
| Lingua: | Inglese |
| Rivista: | |
| Citazione: | Vinciguerra, G. L. R., Noccioli, N., Cippitelli, C., Minucci, A., Capoluongo, E. D., Bartolazzi, A., Oncocytic variant of medullary thyroid carcinoma: a rare case ofsporadic multifocal and bilateral RET wild-type neoplasm with revisionof the literature, <<RARE TUMORS>>, 2016; 8 (4): 166-168. [doi:10.4081/rt.2016.6537] [http://hdl.handle.net/10807/95644] |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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