Oncocytic variant of medullary thyroid carcinoma: a rare case of
sporadic multifocal and bilateral RET wild-type neoplasm with revision
of the literature

Vinciguerra, Gian Luca Rampioni; Noccioli, Niccolo; Cippitelli, Claudia; Minucci, Angelo; Capoluongo, Ettore Domenico; Bartolazzi, Armando

doi:10.4081/rt.2016.6537

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Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are pre sented and discussed with revision of the pertinent literature.

Vinciguerra, G. L. R., Noccioli, N., Cippitelli, C., Minucci, A., Capoluongo, E. D., Bartolazzi, A., Oncocytic variant of medullary thyroid carcinoma: a rare case ofsporadic multifocal and bilateral RET wild-type neoplasm with revisionof the literature, <<RARE TUMORS>>, 2016; 8 (4): 166-168. [doi:10.4081/rt.2016.6537] [http://hdl.handle.net/10807/95644]

Autori:	Vinciguerra, Gian Luca Rampioni Noccioli, Niccolo Cippitelli, Claudia Minucci, Angelo Capoluongo, Ettore Domenico Bartolazzi, Armando Mostra autori esterni Nascondi autori esterni
Titolo:	Oncocytic variant of medullary thyroid carcinoma: a rare case of sporadic multifocal and bilateral RET wild-type neoplasm with revision of the literature
Digital Object Identifier (DOI):	http://dx.doi.org/10.4081/rt.2016.6537
Data di pubblicazione:	2016
Abstract:	Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are pre sented and discussed with revision of the pertinent literature.
Lingua:	Inglese
Rivista:	RARE TUMORS
Citazione:	Vinciguerra, G. L. R., Noccioli, N., Cippitelli, C., Minucci, A., Capoluongo, E. D., Bartolazzi, A., Oncocytic variant of medullary thyroid carcinoma: a rare case ofsporadic multifocal and bilateral RET wild-type neoplasm with revisionof the literature, <<RARE TUMORS>>, 2016; 8 (4): 166-168. [doi:10.4081/rt.2016.6537] [http://hdl.handle.net/10807/95644]
Appare nelle tipologie:	Articolo in rivista, Nota a sentenza

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