Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are pre sented and discussed with revision of the pertinent literature.
Vinciguerra, G. L. R., Noccioli, N., Cippitelli, C., Minucci, A., Capoluongo, E. D., Bartolazzi, A., Oncocytic variant of medullary thyroid carcinoma: a rare case ofsporadic multifocal and bilateral RET wild-type neoplasm with revisionof the literature, <<RARE TUMORS>>, 2016; 8 (4): 166-168. [doi:10.4081/rt.2016.6537] [http://hdl.handle.net/10807/95644]
Autori: | |
Titolo: | Oncocytic variant of medullary thyroid carcinoma: a rare case of sporadic multifocal and bilateral RET wild-type neoplasm with revision of the literature |
Digital Object Identifier (DOI): | http://dx.doi.org/10.4081/rt.2016.6537 |
Data di pubblicazione: | 2016 |
Abstract: | Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are pre sented and discussed with revision of the pertinent literature. |
Lingua: | Inglese |
Rivista: | |
Citazione: | Vinciguerra, G. L. R., Noccioli, N., Cippitelli, C., Minucci, A., Capoluongo, E. D., Bartolazzi, A., Oncocytic variant of medullary thyroid carcinoma: a rare case ofsporadic multifocal and bilateral RET wild-type neoplasm with revisionof the literature, <<RARE TUMORS>>, 2016; 8 (4): 166-168. [doi:10.4081/rt.2016.6537] [http://hdl.handle.net/10807/95644] |
Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |