Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are pre sented and discussed with revision of the pertinent literature.

Vinciguerra, G. L. R., Noccioli, N., Cippitelli, C., Minucci, A., Capoluongo, E. D., Bartolazzi, A., Oncocytic variant of medullary thyroid carcinoma: a rare case ofsporadic multifocal and bilateral RET wild-type neoplasm with revisionof the literature, <<RARE TUMORS>>, 2016; 8 (4): 166-168. [doi:10.4081/rt.2016.6537] [http://hdl.handle.net/10807/95644]

Oncocytic variant of medullary thyroid carcinoma: a rare case of sporadic multifocal and bilateral RET wild-type neoplasm with revision of the literature

Minucci, Angelo;Capoluongo, Ettore Domenico;
2016

Abstract

Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are pre sented and discussed with revision of the pertinent literature.
eng
Vinciguerra, G. L. R., Noccioli, N., Cippitelli, C., Minucci, A., Capoluongo, E. D., Bartolazzi, A., Oncocytic variant of medullary thyroid carcinoma: a rare case ofsporadic multifocal and bilateral RET wild-type neoplasm with revisionof the literature, <>, 2016; 8 (4): 166-168. [doi:10.4081/rt.2016.6537] [http://hdl.handle.net/10807/95644]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/95644
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 6
social impact