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EnglishBackground: Agomelatine modulates brain-derived neurotrophic factor expression via its interaction with melatonergic and serotonergic receptors and has shown promising results in terms of brain-derived neurotrophic factor increase in animal models. Methods: Twenty-seven patients were started on agomelatine (25 mg/d). Venous blood was collected and brain-derived neurotrophic factor serum levels were measured at baseline and after 2 and 8 weeks along with a clinical assessment, including Hamilton Depression Rating Scale and Snaith-Hamilton Pleasure Scale. Results: Brain-derived neurotrophic factor serum concentration increased after agomelatine treatment. Responders showed a significant increase in brain-derived neurotrophic factor levels after 2 weeks of agomelatine treatment; no difference was observed in nonresponders. Linear regression analysis showed that more prominent brain-derived neurotrophic factor level variation was associated with lower baseline BDNF levels and greater anhedonic features at baseline. Conclusions: Patients affected by depressive disorders showed an increase of brain-derived neurotrophic factor serum concentration after a 2-week treatment with agomelatine. The increase of brain-derived neurotrophic factor levels was found to be greater in patients with lower brain-derived neurotrophic factor levels and marked anhedonia at baseline.
| Autori: | |
| Titolo: | Agomelatine increases BDNF serum levels in depressed patients in correlation with the improvement of depressive symptoms |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/ijnp/pyw003 |
| URL: | http://ijnp.oxfordjournals.org/ |
| Data di pubblicazione: | 2016 |
| Abstract: | Background: Agomelatine modulates brain-derived neurotrophic factor expression via its interaction with melatonergic and serotonergic receptors and has shown promising results in terms of brain-derived neurotrophic factor increase in animal models. Methods: Twenty-seven patients were started on agomelatine (25 mg/d). Venous blood was collected and brain-derived neurotrophic factor serum levels were measured at baseline and after 2 and 8 weeks along with a clinical assessment, including Hamilton Depression Rating Scale and Snaith-Hamilton Pleasure Scale. Results: Brain-derived neurotrophic factor serum concentration increased after agomelatine treatment. Responders showed a significant increase in brain-derived neurotrophic factor levels after 2 weeks of agomelatine treatment; no difference was observed in nonresponders. Linear regression analysis showed that more prominent brain-derived neurotrophic factor level variation was associated with lower baseline BDNF levels and greater anhedonic features at baseline. Conclusions: Patients affected by depressive disorders showed an increase of brain-derived neurotrophic factor serum concentration after a 2-week treatment with agomelatine. The increase of brain-derived neurotrophic factor levels was found to be greater in patients with lower brain-derived neurotrophic factor levels and marked anhedonia at baseline. |
| Lingua: | Inglese |
| Rivista: | |
| Citazione: | Martinotti, G., Pettorruso, M., De Berardis, D., Varasano, P. A., Pressanti, G. L., De Remigis, V., Valchera, A., Ricci, V., Di Nicola, M., Janiri, L., Biggio, G., Di Giannantonio, M., Agomelatine increases BDNF serum levels in depressed patients in correlation with the improvement of depressive symptoms, <<INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY>>, 2016; 19 (5): pyw003-N/A. [doi:10.1093/ijnp/pyw003] [http://hdl.handle.net/10807/94655] |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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