Tumors contain a specialized subset of cells with unique properties, such as self-renewal and tumorigenic potential. These cancer stem-like cells (CSCs) are supposed to be responsible for therapeutic resistance and metastatic spread. Functional characterization of breast CSCs (BCSCs) is beginning to shed light on molecular networks which are specifically activated in this cellular compartment, and that account for the retention/acquisition of stem-like features. The Hippo tumor suppressor pathway has increasingly been tied to breast cancer. Altered Hippo activity, or Hippo-independent mechanisms, mediate the activation of the Hippo transducers TAZ and YAP. When this occurs, cancer cells acquire more aggressive traits. In the realm of BCSCs, improper TAZ/YAP activity sustains self-renewal, resistance to conventional anticancer agents, and metastatic dissemination. In this review, we highlight the involvement of TAZ and YAP in mammary gland development and in BCSCs. We also discuss potential strategies for transferring this information into the clinical setting.

Maugeri Saccà, M., De Maria Marchiano, R., Hippo pathway and breast cancer stem cells, <<CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY>>, 2016; 99 (Mar): 115-122. [doi:10.1016/j.critrevonc.2015.12.004] [http://hdl.handle.net/10807/94032]

Hippo pathway and breast cancer stem cells

De Maria Marchiano, Ruggero
2016

Abstract

Tumors contain a specialized subset of cells with unique properties, such as self-renewal and tumorigenic potential. These cancer stem-like cells (CSCs) are supposed to be responsible for therapeutic resistance and metastatic spread. Functional characterization of breast CSCs (BCSCs) is beginning to shed light on molecular networks which are specifically activated in this cellular compartment, and that account for the retention/acquisition of stem-like features. The Hippo tumor suppressor pathway has increasingly been tied to breast cancer. Altered Hippo activity, or Hippo-independent mechanisms, mediate the activation of the Hippo transducers TAZ and YAP. When this occurs, cancer cells acquire more aggressive traits. In the realm of BCSCs, improper TAZ/YAP activity sustains self-renewal, resistance to conventional anticancer agents, and metastatic dissemination. In this review, we highlight the involvement of TAZ and YAP in mammary gland development and in BCSCs. We also discuss potential strategies for transferring this information into the clinical setting.
eng
www.elsevier.com/locate/critrevonc
Maugeri Saccà, M., De Maria Marchiano, R., Hippo pathway and breast cancer stem cells, <>, 2016; 99 (Mar): 115-122. [doi:10.1016/j.critrevonc.2015.12.004] [http://hdl.handle.net/10807/94032]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/94032
Citazioni
  • ???jsp.display-item.citation.pmc??? 23
  • Scopus 34
  • ???jsp.display-item.citation.isi??? 35
social impact