Background: EndoFaster is novel device able to perform real-time ammonium measurement in gastric juice allowing H. pylori diagnosis during endoscopy. This large study aimed to validate the accuracy of EndoFaster for real-time H. pylori detection. Methods: Consecutive patients who underwent upper endoscopy in two centres were prospectively enrolled. During endoscopy, 4 ml of gastric juice were aspirated to perform automatic analysis by EndoFaster within 90 seconds, and H. pylori was considered present (>62 ppm/ml) or absent (≤62 ppm/ml). Accuracy was measured by using histology as gold standard, and 13C-urea breath test (UBT) in discordant cases. Accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) were calculated. Results: Overall, 189 patients were enrolled, but in seven (3.4%) the aspirated gastric juice amount was insufficient to perform the test. The accuracy, sensitivity, specificity, PPV, and NPV were 87.4%, 90.3%, 85.5%, 80.2%, 93.1%, respectively, and 92.6%, 97.1%, 89.7%, 85.9%, 98.0%, respectively, when H. pylori status was reclassified according to the UBT result in discordant cases. Conclusions: This study found a high accuracy/feasibility of EndoFaster for real-time H. pylori diagnosis. Use of EndoFaster may allow selecting those patients in whom routine gastric biopsies could be avoided.

Costamagna, G., Zullo, A., Bizzotto, A., Spada, C., Hassan, C., Riccioni, M. E., Marmo, C., Strangio, G., Di Rienzo, T. A., Cammarota, G., Gasbarrini, A., Repici, A., Real-time diagnosis of H. pylori infection during endoscopy: Accuracy of an innovative tool (EndoFaster), <<UNITED EUROPEAN GASTROENTEROLOGY JOURNAL>>, 2016; 4 (3): 339-342. [doi:10.1177/2050640615610021] [http://hdl.handle.net/10807/93146]

Real-time diagnosis of H. pylori infection during endoscopy: Accuracy of an innovative tool (EndoFaster)

Costamagna, Guido
Primo
;
Bizzotto, Alessandra;Spada, Cristiano
;
Hassan, Cesare;Riccioni, Maria Elena;Cammarota, Giovanni;Gasbarrini, Antonio
Penultimo
;
2016

Abstract

Background: EndoFaster is novel device able to perform real-time ammonium measurement in gastric juice allowing H. pylori diagnosis during endoscopy. This large study aimed to validate the accuracy of EndoFaster for real-time H. pylori detection. Methods: Consecutive patients who underwent upper endoscopy in two centres were prospectively enrolled. During endoscopy, 4 ml of gastric juice were aspirated to perform automatic analysis by EndoFaster within 90 seconds, and H. pylori was considered present (>62 ppm/ml) or absent (≤62 ppm/ml). Accuracy was measured by using histology as gold standard, and 13C-urea breath test (UBT) in discordant cases. Accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) were calculated. Results: Overall, 189 patients were enrolled, but in seven (3.4%) the aspirated gastric juice amount was insufficient to perform the test. The accuracy, sensitivity, specificity, PPV, and NPV were 87.4%, 90.3%, 85.5%, 80.2%, 93.1%, respectively, and 92.6%, 97.1%, 89.7%, 85.9%, 98.0%, respectively, when H. pylori status was reclassified according to the UBT result in discordant cases. Conclusions: This study found a high accuracy/feasibility of EndoFaster for real-time H. pylori diagnosis. Use of EndoFaster may allow selecting those patients in whom routine gastric biopsies could be avoided.
2016
Inglese
Costamagna, G., Zullo, A., Bizzotto, A., Spada, C., Hassan, C., Riccioni, M. E., Marmo, C., Strangio, G., Di Rienzo, T. A., Cammarota, G., Gasbarrini, A., Repici, A., Real-time diagnosis of H. pylori infection during endoscopy: Accuracy of an innovative tool (EndoFaster), <<UNITED EUROPEAN GASTROENTEROLOGY JOURNAL>>, 2016; 4 (3): 339-342. [doi:10.1177/2050640615610021] [http://hdl.handle.net/10807/93146]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/93146
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