Carbohydrate 19-9 antigen (CA 19-9) is considered a specific marker of pancreatobiliary adenocarcinomas, but slight increase of its levels can be found in several non-malignant diseases of the liver, such as autoimmune hepatitis. We describe a case of marked CA 19-9 elevation (up to 898.0 U/ml) in a patient with autoimmune hepatitis. Laboratory and instrumental examinations excluded malignant diseases. Immunohistochemical analysis for CA 19-9 and MIB-1, performed on liver biopsy, showed reactivity in inflammatory areas, in particular in bile ductule cells and hepatocytes in ductular metaplasia, suggesting that these cells could be involved in CA 19-9 serum levels increase. After steroids, the clinical picture improved and all the laboratory parameters normalised.

Montalto, M., Santoro, L., Vastola, M., Curigliano, V., Ricci, R., Vecchio, F. M., Manna, R., Gasbarrini, G. B., Normalisation of high CA 19-9 values in autoimmune hepatitis after steroidal treatment., <<INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY>>, 2005; (18): 603-608 [http://hdl.handle.net/10807/93111]

Normalisation of high CA 19-9 values in autoimmune hepatitis after steroidal treatment.

Montalto, Massimo;Santoro, Luca;Vastola, Monica;Curigliano, Valentina;Ricci, Riccardo;Vecchio, Fabio Maria;Manna, Raffaele;Gasbarrini, Giovanni Battista
2005

Abstract

Carbohydrate 19-9 antigen (CA 19-9) is considered a specific marker of pancreatobiliary adenocarcinomas, but slight increase of its levels can be found in several non-malignant diseases of the liver, such as autoimmune hepatitis. We describe a case of marked CA 19-9 elevation (up to 898.0 U/ml) in a patient with autoimmune hepatitis. Laboratory and instrumental examinations excluded malignant diseases. Immunohistochemical analysis for CA 19-9 and MIB-1, performed on liver biopsy, showed reactivity in inflammatory areas, in particular in bile ductule cells and hepatocytes in ductular metaplasia, suggesting that these cells could be involved in CA 19-9 serum levels increase. After steroids, the clinical picture improved and all the laboratory parameters normalised.
Inglese
Montalto, M., Santoro, L., Vastola, M., Curigliano, V., Ricci, R., Vecchio, F. M., Manna, R., Gasbarrini, G. B., Normalisation of high CA 19-9 values in autoimmune hepatitis after steroidal treatment., <>, 2005; (18): 603-608 [http://hdl.handle.net/10807/93111]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/93111
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