Objective: The aim of the study was to assess the value and potential pitfalls of 68Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) in patients with suspected pancreatic neuroendocrine neoplasms (pNEN). Methods: Consecutive patients referred for 68Ga-DOTANOC PET/CT for suspected pNENbetweenMay 1, 2011, andOctober 31, 2014, were retrospectively assessed. Scan data were compared with cytological/ histological final diagnosis. Pancreatic neuroendocrine neoplasm detection rate was determined on per-patient and per-lesion basis. Maximum standardized uptake values of lesions were determined. Results: Fifty-eight patients with 65 lesions were enrolled. Twelve patients had nonconfirmed diagnosis; of these, 7 were positive and 5 negative at PET/CT. Of 46 patients with confirmed diagnosis, 36 had pNEN; of these, 33 were positive, 1 negative, and 2 nonevaluable at PET/CT. Ten patients had non-NE lesions, of which 8 were positive, 1 negative, and 1 nonevaluable at PET/CT. Of 48 patients with positive PET/CT, 8 proved to have non-NE lesions, of which 6 were intrapancreatic accessory spleen. No significant maximum standardized uptake values difference was found between pNEN and non-NE lesions. Conclusions: Intrapancreatic accessory spleen is an important pitfall in 68Ga-DOTANOC PET/CT for suspected pNEN. Cytological/histological confirmation is mandatory before any surgical procedure is undertaken.

Rufini, V., Inzani, F., Stefanelli, A., Castaldi, P., Perotti, G., Cinquino, A., Indovina, L., Rindi, G., The accessory spleen is an important pitfall of 68Ga-DOTANOC PET/CT in the workup for pancreatic neuroendocrine neoplasm, <<PANCREAS>>, 2017; 46 (2): 157-163. [doi:10.1097/MPA.0000000000000728] [http://hdl.handle.net/10807/92938]

The accessory spleen is an important pitfall of 68Ga-DOTANOC PET/CT in the workup for pancreatic neuroendocrine neoplasm

Rufini, Vittoria
Primo
;
Inzani, Frediano
Secondo
;
Stefanelli, Antonella;Castaldi, Paola;Perotti, Germano;Cinquino, Annarita;Indovina, Luca
Penultimo
;
Rindi, Guido
Ultimo
2017

Abstract

Objective: The aim of the study was to assess the value and potential pitfalls of 68Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) in patients with suspected pancreatic neuroendocrine neoplasms (pNEN). Methods: Consecutive patients referred for 68Ga-DOTANOC PET/CT for suspected pNENbetweenMay 1, 2011, andOctober 31, 2014, were retrospectively assessed. Scan data were compared with cytological/ histological final diagnosis. Pancreatic neuroendocrine neoplasm detection rate was determined on per-patient and per-lesion basis. Maximum standardized uptake values of lesions were determined. Results: Fifty-eight patients with 65 lesions were enrolled. Twelve patients had nonconfirmed diagnosis; of these, 7 were positive and 5 negative at PET/CT. Of 46 patients with confirmed diagnosis, 36 had pNEN; of these, 33 were positive, 1 negative, and 2 nonevaluable at PET/CT. Ten patients had non-NE lesions, of which 8 were positive, 1 negative, and 1 nonevaluable at PET/CT. Of 48 patients with positive PET/CT, 8 proved to have non-NE lesions, of which 6 were intrapancreatic accessory spleen. No significant maximum standardized uptake values difference was found between pNEN and non-NE lesions. Conclusions: Intrapancreatic accessory spleen is an important pitfall in 68Ga-DOTANOC PET/CT for suspected pNEN. Cytological/histological confirmation is mandatory before any surgical procedure is undertaken.
Inglese
Rufini, V., Inzani, F., Stefanelli, A., Castaldi, P., Perotti, G., Cinquino, A., Indovina, L., Rindi, G., The accessory spleen is an important pitfall of 68Ga-DOTANOC PET/CT in the workup for pancreatic neuroendocrine neoplasm, <<PANCREAS>>, 2017; 46 (2): 157-163. [doi:10.1097/MPA.0000000000000728] [http://hdl.handle.net/10807/92938]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/92938
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