Benzodiazepines (BZDs) are among the most widely prescribed drugs in developed countries, but they have a high potential for tolerance, dependence and misuse. High-dose BZD misuse represents an emerging addiction phenomenon, but data on quality of life (QoL) in high-dose BZD misusers are scant. This study aimed to explore QoL in high-dose BZD misuse. We recruited 267 high-dose BZD misusers, compared the QoL scores in those who took BZD only to poly-drug misusers, and explored the role of demographic and clinical covariates through multivariable analysis. Our data confirmed worse QoL in high-dose BZD misusers and showed that (a) QoL scores were not negatively influenced by the misuse of alcohol or other drugs, or by coexisting psychiatric disorders; (b) demographic variables turned out to be the most significant predictors of QoL scores; (c) BZD intake significantly and negatively influenced QoL. Physical and psychological dimensions of QoL are significantly lower in high-dose BZD misusers with no significant effect of comorbidities. Our data suggest that the main reason for poor QoL in these patients is high-dose BZD intake per se. QoL should be considered among outcome measures in these patients.

Tamburin, S., Federico, A., Faccini, M., Casari, R., Morbioli, L., Sartore, V., Mirijello, A., Addolorato, G., Lugoboni, F., Determinants of Quality of Life in High-Dose Benzodiazepine Misusers., <<INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH>>, 2017; (gennaio): 38-38. [doi:10.3390/ijerph14010038] [http://hdl.handle.net/10807/92854]

Determinants of Quality of Life in High-Dose Benzodiazepine Misusers.

Mirijello, Antonio;Addolorato, Giovanni;
2017

Abstract

Benzodiazepines (BZDs) are among the most widely prescribed drugs in developed countries, but they have a high potential for tolerance, dependence and misuse. High-dose BZD misuse represents an emerging addiction phenomenon, but data on quality of life (QoL) in high-dose BZD misusers are scant. This study aimed to explore QoL in high-dose BZD misuse. We recruited 267 high-dose BZD misusers, compared the QoL scores in those who took BZD only to poly-drug misusers, and explored the role of demographic and clinical covariates through multivariable analysis. Our data confirmed worse QoL in high-dose BZD misusers and showed that (a) QoL scores were not negatively influenced by the misuse of alcohol or other drugs, or by coexisting psychiatric disorders; (b) demographic variables turned out to be the most significant predictors of QoL scores; (c) BZD intake significantly and negatively influenced QoL. Physical and psychological dimensions of QoL are significantly lower in high-dose BZD misusers with no significant effect of comorbidities. Our data suggest that the main reason for poor QoL in these patients is high-dose BZD intake per se. QoL should be considered among outcome measures in these patients.
Inglese
Tamburin, S., Federico, A., Faccini, M., Casari, R., Morbioli, L., Sartore, V., Mirijello, A., Addolorato, G., Lugoboni, F., Determinants of Quality of Life in High-Dose Benzodiazepine Misusers., <>, 2017; (gennaio): 38-38. [doi:10.3390/ijerph14010038] [http://hdl.handle.net/10807/92854]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/92854
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