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EnglishObjective Epilepsy is characterized by unpredictable and sudden paroxysmal neuronal firing occurrences and sometimes evolving in clinically evident seizure. To predict seizure event, small-world characteristic in nine minutes before seizure, divided in three 3-min periods (T0, T1, T2) were investigated. Methods Intracerebral recordings were obtained from 10 patients with drug resistant focal epilepsy examined by means of stereotactically implanted electrodes; analysis was focused in a period of low spiking (Baseline) and during two seizures. Networks’ architecture is undirected and weighted. Electrodes’ contacts close to epileptic focus are the vertices, edges are weighted by mscohere (=magnitude squared coherence). Results Differences were observed between Baseline and T1 and between Baseline and T2 in theta band; and between Baseline and T1, Baseline and T2, and near-significant difference between T0 and T2 in Alpha 2 band. Moreover, an intra-band index was computed for small worldness as difference between Theta and Alpha 2. It was found a growing index trend from Baseline to T2. Conclusions Cortical network features a specific pre-seizure architecture which could predict the incoming epileptic seizure. Significance Through this study future researches could investigate brain connectivity modifications approximating a clinical seizure also in order to address a preventive therapy.
Vecchio, F., Miraglia, F., Vollono, C., Fuggetta, F., Bramanti, P., Cioni, B., Rossini, P. M., Pre-seizure architecture of the local connections of the epileptic focus examined via graph-theory, <<CLINICAL NEUROPHYSIOLOGY>>, 2016; 127 (10): 3252-3258. [doi:10.1016/j.clinph.2016.07.006] [http://hdl.handle.net/10807/92779]
| Autori: | |
| Titolo: | Pre-seizure architecture of the local connections of the epileptic focus examined via graph-theory |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.clinph.2016.07.006 |
| URL: | www.elsevier.com/inca/publications/store/6/0/1/5/2/8 |
| Data di pubblicazione: | 2016 |
| Abstract: | Objective Epilepsy is characterized by unpredictable and sudden paroxysmal neuronal firing occurrences and sometimes evolving in clinically evident seizure. To predict seizure event, small-world characteristic in nine minutes before seizure, divided in three 3-min periods (T0, T1, T2) were investigated. Methods Intracerebral recordings were obtained from 10 patients with drug resistant focal epilepsy examined by means of stereotactically implanted electrodes; analysis was focused in a period of low spiking (Baseline) and during two seizures. Networks’ architecture is undirected and weighted. Electrodes’ contacts close to epileptic focus are the vertices, edges are weighted by mscohere (=magnitude squared coherence). Results Differences were observed between Baseline and T1 and between Baseline and T2 in theta band; and between Baseline and T1, Baseline and T2, and near-significant difference between T0 and T2 in Alpha 2 band. Moreover, an intra-band index was computed for small worldness as difference between Theta and Alpha 2. It was found a growing index trend from Baseline to T2. Conclusions Cortical network features a specific pre-seizure architecture which could predict the incoming epileptic seizure. Significance Through this study future researches could investigate brain connectivity modifications approximating a clinical seizure also in order to address a preventive therapy. |
| Lingua: | Inglese |
| Rivista: | |
| Citazione: | Vecchio, F., Miraglia, F., Vollono, C., Fuggetta, F., Bramanti, P., Cioni, B., Rossini, P. M., Pre-seizure architecture of the local connections of the epileptic focus examined via graph-theory, <<CLINICAL NEUROPHYSIOLOGY>>, 2016; 127 (10): 3252-3258. [doi:10.1016/j.clinph.2016.07.006] [http://hdl.handle.net/10807/92779] |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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