Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.
Zanetti, S., Bua, A., Delogu, G., Pusceddu, C., Mura, M., Saba, F., Pirina, P., Garzelli, C., Vertuccio, C., Sechi, L., Fadda, G., Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin, <<CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY>>, 2005; 12 (9): 1135-1138. [doi:10.1128/CDLI.12.9.1135-1138.2005] [http://hdl.handle.net/10807/9225]
Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin
Bua, Alessandra;Delogu, Giovanni;Pusceddu, Cinzia;Fadda, Giovanni
2005
Abstract
Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.
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