In the last years, life-threatening fungal diseases have increased signifi cantly, due to the rising number of human individuals susceptible to fungal infections, which are in part complicated by the emergence of antifungal drug-resistant pathogens. Among yeasts, Candida albicans and Candida glabrata are the most common organisms responsible for invasive fungal diseases. The molecular detection of echinocandin resistance in Candida species may represent a useful means of monitoring the incidence of clinical isolates with antifungal resistance-associated gene alterations. Here, we describe the current methods that enable researchers and/or clinical microbiologists to accurately detect echinocandin-resistant isolates of C. albicans and C. glabrata .
Posteraro, B., Vella, A., De Carolis, E., Sanguinetti, M., Molecular detection of resistance to echinocandins, <<METHODS IN MOLECULAR BIOLOGY>>, 2017; 1508 (1508): 413-421. [doi:10.1007/978-1-4939-6515-1_23] [http://hdl.handle.net/10807/92072]
Molecular detection of resistance to echinocandins
Posteraro, Brunella
;Vella, AntoniettaSecondo
;De Carolis, ElenaPenultimo
;Sanguinetti, MaurizioUltimo
2017
Abstract
In the last years, life-threatening fungal diseases have increased signifi cantly, due to the rising number of human individuals susceptible to fungal infections, which are in part complicated by the emergence of antifungal drug-resistant pathogens. Among yeasts, Candida albicans and Candida glabrata are the most common organisms responsible for invasive fungal diseases. The molecular detection of echinocandin resistance in Candida species may represent a useful means of monitoring the incidence of clinical isolates with antifungal resistance-associated gene alterations. Here, we describe the current methods that enable researchers and/or clinical microbiologists to accurately detect echinocandin-resistant isolates of C. albicans and C. glabrata .
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