l-Glutamate but not methyl-D-aspartate (NMDA) or quisqualate ( Quis ) (10(-6 M) in vitro with or without preincubation increased significantly the KD value of the [3H]N-propylnorapomorphine ( [3H]NPA) binding sites by 21 and 36% respectively in striatal membranes of rat without influencing the striatal [3H]spiperone binding sites. The number of striatal [3H]NPA binding sites was not changed by l-glutamate (10(-6) and 10(-5) M) in vitro. There may thus exist interactions between striatal glutamate receptors -- not related to excitatory amino-acid receptors of the NMDA or the QUIS type -- and high affinity striatal DA receptors.

Fuxe, K., Celani, M., Martire, M., Zini, I., Zoli, M., Agnati, L., l-Glutamate reduces the affinity of [3H]N-propylnorapomorphine binding sites in striatal membranes, <<EUROPEAN JOURNAL OF PHARMACOLOGY>>, 1984; 100 (1): 127-130 [http://hdl.handle.net/10807/9185]

l-Glutamate reduces the affinity of [3H]N-propylnorapomorphine binding sites in striatal membranes

Martire, Maria;
1984

Abstract

l-Glutamate but not methyl-D-aspartate (NMDA) or quisqualate ( Quis ) (10(-6 M) in vitro with or without preincubation increased significantly the KD value of the [3H]N-propylnorapomorphine ( [3H]NPA) binding sites by 21 and 36% respectively in striatal membranes of rat without influencing the striatal [3H]spiperone binding sites. The number of striatal [3H]NPA binding sites was not changed by l-glutamate (10(-6) and 10(-5) M) in vitro. There may thus exist interactions between striatal glutamate receptors -- not related to excitatory amino-acid receptors of the NMDA or the QUIS type -- and high affinity striatal DA receptors.
1984
Inglese
Fuxe, K., Celani, M., Martire, M., Zini, I., Zoli, M., Agnati, L., l-Glutamate reduces the affinity of [3H]N-propylnorapomorphine binding sites in striatal membranes, <<EUROPEAN JOURNAL OF PHARMACOLOGY>>, 1984; 100 (1): 127-130 [http://hdl.handle.net/10807/9185]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/9185
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