Objective Cervical cancer is the most common gynecological cancer occurring in pregnancy, creating a complex situation both for patient and physician. Neoadjuvant chemotherapy is an innovative way of managing cervical cancer in pregnancy. Methods In our paper, we report a retrospective case series of 4 women treated with chemotherapy for invasive cervical cancer during pregnancy in our center over the last 5 years, and we summarize the available literature and guidelines. Results All the cases were locally advanced cervical cancers that received chemotherapy with platinum and/or taxanes. All patients showed a good response to chemotherapy and a radical surgery was performed with no additional morbidities at the cesarean delivery time in 3 of 4 cases. Three of 4 patients are alive and have a good outcome with no recurrence of disease up to date. One patient died because of recurrent disease 2 years after the first-line treatment during pregnancy. All babies are alive and well up to date (maximum follow-up, 63 months). Conclusions Even if there are no standardized practices in the treatment of cervical cancer in pregnancy, in our opinion, neoadjuvant chemotherapy can be a very useful strategy for patients and physicians facing the challenge.

Ricci, C., Scambia, G., De Vincenzo, R. P., Locally Advanced Cervical Cancer in Pregnancy, <<INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER>>, 2016; 26 (8): 1490-1496. [doi:10.1097/IGC.0000000000000795] [http://hdl.handle.net/10807/91740]

Locally Advanced Cervical Cancer in Pregnancy

Ricci, Caterina
Primo
;
Scambia, Giovanni
Secondo
;
De Vincenzo, Rosa Pasqualina
2016

Abstract

Objective Cervical cancer is the most common gynecological cancer occurring in pregnancy, creating a complex situation both for patient and physician. Neoadjuvant chemotherapy is an innovative way of managing cervical cancer in pregnancy. Methods In our paper, we report a retrospective case series of 4 women treated with chemotherapy for invasive cervical cancer during pregnancy in our center over the last 5 years, and we summarize the available literature and guidelines. Results All the cases were locally advanced cervical cancers that received chemotherapy with platinum and/or taxanes. All patients showed a good response to chemotherapy and a radical surgery was performed with no additional morbidities at the cesarean delivery time in 3 of 4 cases. Three of 4 patients are alive and have a good outcome with no recurrence of disease up to date. One patient died because of recurrent disease 2 years after the first-line treatment during pregnancy. All babies are alive and well up to date (maximum follow-up, 63 months). Conclusions Even if there are no standardized practices in the treatment of cervical cancer in pregnancy, in our opinion, neoadjuvant chemotherapy can be a very useful strategy for patients and physicians facing the challenge.
Inglese
Ricci, C., Scambia, G., De Vincenzo, R. P., Locally Advanced Cervical Cancer in Pregnancy, <<INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER>>, 2016; 26 (8): 1490-1496. [doi:10.1097/IGC.0000000000000795] [http://hdl.handle.net/10807/91740]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/91740
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