OBJECTIVE: Type 1 diabetes is associated with increased platelet reactivity. We investigated whether α-lipoic acid (ALA) has any effect on platelet reactivity in these patients. RESEARCH DESIGN AND METHODS: We randomly assigned 51 type 1 diabetic patients to ALA (600 mg once daily) or placebo for 5 weeks. Platelet reactivity was evaluated by the PFA-100 method and by measuring CD41 and CD62 platelet expression. C-reactive protein (CRP) and 8-iso-prostaglandin F2α serum levels also were measured. RESULTS: Baseline variables were similar in the two groups. After treatment, closure time was longer (P = 0.006) and CD62P platelet expression was lower, both before (P = 0.002) and after (P = 0.009) ADP stimulation in the ALA group compared with the placebo group. CRP and 8-iso-prostaglandin F2α levels showed no differences between the two groups. CONCLUSIONS: Our data show that ALA reduces measures of platelet reactivity ex vivo in type 1 diabetic patients, independently of antioxidant or anti-inflammatory effects.

Mollo, R., Zaccardi, F., Scalone, G., Macchione, A., Scavone, G., Rizzo, P., Navarese, E. P., Manto, A., Pitocco, D., Lanza, G. A., Ghirlanda, G., Crea, F., Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients, <<DIABETES CARE>>, 2012; 36 (Febbraio): 196-197. [doi:10.2337/dc11-1255] [http://hdl.handle.net/10807/9058]

Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients

Mollo, Roberto;Zaccardi, Francesco;Scalone, Giancarla;Macchione, Andrea;Scavone, Giuseppe;Rizzo, Paola;Navarese, Eliano Pio;Pitocco, Dario;Lanza, Gaetano Antonio;Ghirlanda, Giovanni;Crea, Filippo
2012

Abstract

OBJECTIVE: Type 1 diabetes is associated with increased platelet reactivity. We investigated whether α-lipoic acid (ALA) has any effect on platelet reactivity in these patients. RESEARCH DESIGN AND METHODS: We randomly assigned 51 type 1 diabetic patients to ALA (600 mg once daily) or placebo for 5 weeks. Platelet reactivity was evaluated by the PFA-100 method and by measuring CD41 and CD62 platelet expression. C-reactive protein (CRP) and 8-iso-prostaglandin F2α serum levels also were measured. RESULTS: Baseline variables were similar in the two groups. After treatment, closure time was longer (P = 0.006) and CD62P platelet expression was lower, both before (P = 0.002) and after (P = 0.009) ADP stimulation in the ALA group compared with the placebo group. CRP and 8-iso-prostaglandin F2α levels showed no differences between the two groups. CONCLUSIONS: Our data show that ALA reduces measures of platelet reactivity ex vivo in type 1 diabetic patients, independently of antioxidant or anti-inflammatory effects.
Inglese
Mollo, R., Zaccardi, F., Scalone, G., Macchione, A., Scavone, G., Rizzo, P., Navarese, E. P., Manto, A., Pitocco, D., Lanza, G. A., Ghirlanda, G., Crea, F., Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients, <>, 2012; 36 (Febbraio): 196-197. [doi:10.2337/dc11-1255] [http://hdl.handle.net/10807/9058]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/9058
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