The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration.

Sprio, S., Dapporto, M., Montesi, M., Panseri, S., Lattanzi, W., Pola, E., Logroscino, G., Tampieri, A., Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate, <<MATERIALS>>, 2016; 9 (9): 763-781. [doi:10.3390/ma9090763] [http://hdl.handle.net/10807/87201]

Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

Silvia; Lattanzi;Wanda; Pola;Enrico; Logroscino
Penultimo
;
2016

Abstract

The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration.
Inglese
Sprio, S., Dapporto, M., Montesi, M., Panseri, S., Lattanzi, W., Pola, E., Logroscino, G., Tampieri, A., Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate, <<MATERIALS>>, 2016; 9 (9): 763-781. [doi:10.3390/ma9090763] [http://hdl.handle.net/10807/87201]
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