The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.

De Candia, A., Gamba, A., Cavalli, F., Coniglio, A., Di Talia, S., Bussolino, F., Serini, G., A simulation environment for directional sensing as a phase separation process, <<SCIENCE'S STKE: SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT>>, 2007; 2007 (378): N/A-N/A. [doi:10.1126/stke.3782007pl1] [http://hdl.handle.net/10807/85717]

A simulation environment for directional sensing as a phase separation process

Cavalli, Fausto;
2007

Abstract

The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.
Inglese
De Candia, A., Gamba, A., Cavalli, F., Coniglio, A., Di Talia, S., Bussolino, F., Serini, G., A simulation environment for directional sensing as a phase separation process, <>, 2007; 2007 (378): N/A-N/A. [doi:10.1126/stke.3782007pl1] [http://hdl.handle.net/10807/85717]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/85717
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 5
  • ???jsp.display-item.citation.isi??? ND
social impact