The term aspirin resistance has been used increasingly in clinical studies. The aim of this Review is to analyze the origin of this term, to discuss the biochemical, functional and clinical correlates of the phenomenon and to offer a conceptual framework to redefine the major determinants of variability between individuals in response to aspirin. Awareness needs to be increased of factors that might interfere with the desired antiplatelet effect of aspirin, particularly in terms of patients' adherence to treatment and avoidable drug interactions with some traditional NSAIDs. Gaining such knowledge could result in improved care of patients and might avoid the requesting of unnecessary platelet function tests of unproven clinical significance.

Patrono, C., Rocca, B., Drug insight: aspirin resistance- fact or fashion, <<NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE>>, 2007; (4): 42-50 [http://hdl.handle.net/10807/8522]

Drug insight: aspirin resistance- fact or fashion

Patrono, Carlo;Rocca, Bianca
2007

Abstract

The term aspirin resistance has been used increasingly in clinical studies. The aim of this Review is to analyze the origin of this term, to discuss the biochemical, functional and clinical correlates of the phenomenon and to offer a conceptual framework to redefine the major determinants of variability between individuals in response to aspirin. Awareness needs to be increased of factors that might interfere with the desired antiplatelet effect of aspirin, particularly in terms of patients' adherence to treatment and avoidable drug interactions with some traditional NSAIDs. Gaining such knowledge could result in improved care of patients and might avoid the requesting of unnecessary platelet function tests of unproven clinical significance.
Inglese
Patrono, C., Rocca, B., Drug insight: aspirin resistance- fact or fashion, <>, 2007; (4): 42-50 [http://hdl.handle.net/10807/8522]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/8522
Citazioni
  • ???jsp.display-item.citation.pmc??? 26
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact