Adult neurogenesis initiated by neural stem cells (NSCs) contributes to brain homeostasis, damage repair, and cognition. Energy metabolism plays a pivotal role in neurogenic cell fate decisions regarding self-renewal, expansion and multilineage differentiation. NSCs need to fine-tune quiescence and proliferation/commitment to guarantee lifelong neurogenesis and avoid premature exhaustion. Accumulating evidence supports a model whereby calorie restriction or increased energy expenditure reinforce NSC quiescence and promote self-renewal. Conversely, growth/proliferation inputs and anabolic signals, although necessary for neurogenesis, deplete the NSCs pool in the long run. This framework incorporates the emerging neurogenic roles of nutrient-sensing signaling pathways, providing a rationale for the alarming connection between nutritional imbalances, metabolic disorders and accelerated brain aging.

Cavallucci, V., Fidaleo, M., Pani, G., Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion, <<TRENDS IN ENDOCRINOLOGY AND METABOLISM>>, 2016; (11): 756-769. [doi:10.1016/j.tem.2016.06.007] [http://hdl.handle.net/10807/84847]

Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion

Cavallucci, Virve
Primo
;
Fidaleo, Marco
Secondo
;
Pani, Giovambattista
Ultimo
2016

Abstract

Adult neurogenesis initiated by neural stem cells (NSCs) contributes to brain homeostasis, damage repair, and cognition. Energy metabolism plays a pivotal role in neurogenic cell fate decisions regarding self-renewal, expansion and multilineage differentiation. NSCs need to fine-tune quiescence and proliferation/commitment to guarantee lifelong neurogenesis and avoid premature exhaustion. Accumulating evidence supports a model whereby calorie restriction or increased energy expenditure reinforce NSC quiescence and promote self-renewal. Conversely, growth/proliferation inputs and anabolic signals, although necessary for neurogenesis, deplete the NSCs pool in the long run. This framework incorporates the emerging neurogenic roles of nutrient-sensing signaling pathways, providing a rationale for the alarming connection between nutritional imbalances, metabolic disorders and accelerated brain aging.
Inglese
Cavallucci, V., Fidaleo, M., Pani, G., Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion, <<TRENDS IN ENDOCRINOLOGY AND METABOLISM>>, 2016; (11): 756-769. [doi:10.1016/j.tem.2016.06.007] [http://hdl.handle.net/10807/84847]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/84847
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