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EnglishAdult neurogenesis initiated by neural stem cells (NSCs) contributes to brain homeostasis, damage repair, and cognition. Energy metabolism plays a pivotal role in neurogenic cell fate decisions regarding self-renewal, expansion and multilineage differentiation. NSCs need to fine-tune quiescence and proliferation/commitment to guarantee lifelong neurogenesis and avoid premature exhaustion. Accumulating evidence supports a model whereby calorie restriction or increased energy expenditure reinforce NSC quiescence and promote self-renewal. Conversely, growth/proliferation inputs and anabolic signals, although necessary for neurogenesis, deplete the NSCs pool in the long run. This framework incorporates the emerging neurogenic roles of nutrient-sensing signaling pathways, providing a rationale for the alarming connection between nutritional imbalances, metabolic disorders and accelerated brain aging.
Cavallucci, V., Fidaleo, M., Pani, G., Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion, <<TRENDS IN ENDOCRINOLOGY AND METABOLISM>>, 2016; (11): 756-769. [doi:10.1016/j.tem.2016.06.007] [http://hdl.handle.net/10807/84847]
| Autori: | |
| Titolo: | Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.tem.2016.06.007 |
| Data di pubblicazione: | 2016 |
| Abstract: | Adult neurogenesis initiated by neural stem cells (NSCs) contributes to brain homeostasis, damage repair, and cognition. Energy metabolism plays a pivotal role in neurogenic cell fate decisions regarding self-renewal, expansion and multilineage differentiation. NSCs need to fine-tune quiescence and proliferation/commitment to guarantee lifelong neurogenesis and avoid premature exhaustion. Accumulating evidence supports a model whereby calorie restriction or increased energy expenditure reinforce NSC quiescence and promote self-renewal. Conversely, growth/proliferation inputs and anabolic signals, although necessary for neurogenesis, deplete the NSCs pool in the long run. This framework incorporates the emerging neurogenic roles of nutrient-sensing signaling pathways, providing a rationale for the alarming connection between nutritional imbalances, metabolic disorders and accelerated brain aging. |
| Lingua: | Inglese |
| Rivista: | |
| Citazione: | Cavallucci, V., Fidaleo, M., Pani, G., Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion, <<TRENDS IN ENDOCRINOLOGY AND METABOLISM>>, 2016; (11): 756-769. [doi:10.1016/j.tem.2016.06.007] [http://hdl.handle.net/10807/84847] |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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