In the model of trimethyltin (TMT)-induced neurodegeneration in developing rat hippocampus, calretinin (CR)-immunoreactive neurons are selectively spared and even more numerous than in controls. We investigated the possibility of an additional synthesis of CR using RT-PCR. The amount of CR mRNA increased significantly after TMT treatment. CR mRNA production after TMT treatment could hypothetically be regarded as a compensatory phenomenon in developing rats.
Businaro, R., Corvino, V., Geloso, M. C., De Santis, E., Fumagalli, L., Michetti, F., De novo expression of calretinin in trimethyltin-induced degeneration of developing rat hippocampus, <<MOLECULAR BRAIN RESEARCH>>, 2002; (98(1-2)): 141-144 [http://hdl.handle.net/10807/8200]
De novo expression of calretinin in trimethyltin-induced degeneration of developing rat hippocampus
Corvino, Valentina;Geloso, Maria Concetta;De Santis, Elena;Michetti, Fabrizio
2002
Abstract
In the model of trimethyltin (TMT)-induced neurodegeneration in developing rat hippocampus, calretinin (CR)-immunoreactive neurons are selectively spared and even more numerous than in controls. We investigated the possibility of an additional synthesis of CR using RT-PCR. The amount of CR mRNA increased significantly after TMT treatment. CR mRNA production after TMT treatment could hypothetically be regarded as a compensatory phenomenon in developing rats.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
