The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines of Italian autistic children up to 8 years of age. The present study aims at replicating these initial findings in an ethnically distinct sample and at extending them by measuring also the three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol. Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33 French autism spectrum disorder (ASD) cases compared with 33 sex-and age-matched controls (p<0.05). This increase was limited to ASD children aged <= 8 years (p<0.01), and not older (p=0.17). Urinary levels of p-cresol and p-cresylsulfate were associated with stereotypic, compulsive/repetitive behaviors (p<0.05), although not with overall autism severity. These results confirm the elevation of urinary p-cresol in a sizable set of small autistic children and spur interest into biomarker roles for p-cresol and p-cresylsulfate in autism.

Gabriele, S., Sacco, R., Cerullo, S., Neri, C., Urbani, A., Tripi, G., Malvy, J., Barthelemy, C., Bonnet Brilhault, F., Persico, A., Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study, <<BIOMARKERS>>, 2014; 19 (6): 463-470. [doi:10.3109/1354750X.2014.936911] [http://hdl.handle.net/10807/79497]

Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study

C; Urbani;
2014

Abstract

The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines of Italian autistic children up to 8 years of age. The present study aims at replicating these initial findings in an ethnically distinct sample and at extending them by measuring also the three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol. Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33 French autism spectrum disorder (ASD) cases compared with 33 sex-and age-matched controls (p<0.05). This increase was limited to ASD children aged <= 8 years (p<0.01), and not older (p=0.17). Urinary levels of p-cresol and p-cresylsulfate were associated with stereotypic, compulsive/repetitive behaviors (p<0.05), although not with overall autism severity. These results confirm the elevation of urinary p-cresol in a sizable set of small autistic children and spur interest into biomarker roles for p-cresol and p-cresylsulfate in autism.
Inglese
Gabriele, S., Sacco, R., Cerullo, S., Neri, C., Urbani, A., Tripi, G., Malvy, J., Barthelemy, C., Bonnet Brilhault, F., Persico, A., Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study, <<BIOMARKERS>>, 2014; 19 (6): 463-470. [doi:10.3109/1354750X.2014.936911] [http://hdl.handle.net/10807/79497]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/79497
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