The conversion of cells with an epithelial phenotype into cells with a mesenchymal phenotype, referred to as epithelial-mesenchymal transition, is a critical process for embryonic development that also occurs in adult life, particularly during tumour progression. Tumour cells undergoing epithelial-mesenchymal transition acquire the capacity to disarm the body's antitumour defences, resist apoptosis and anticancer drugs, disseminate throughout the organism, and act as a reservoir that replenishes and expands the tumour cell population. Epithelial-mesenchymal transition is therefore becoming a target of prime interest for anticancer therapy. Here, we discuss the screening and classification of compounds that affect epithelial-mesenchymal transition, highlight some compounds of particular interest, and address issues related to their clinical application.

Marcucci, F., Stassi, G., De Maria Marchiano, R., Epithelial-mesenchymal transition: a new target in anticancer drug discovery, <<NATURE REVIEWS DRUG DISCOVERY>>, 2015; 15 (5): 311-325. [doi:10.1038/nrd.2015.13] [http://hdl.handle.net/10807/79477]

Epithelial-mesenchymal transition: a new target in anticancer drug discovery

De Maria Marchiano, Ruggero
Ultimo
2016

Abstract

The conversion of cells with an epithelial phenotype into cells with a mesenchymal phenotype, referred to as epithelial-mesenchymal transition, is a critical process for embryonic development that also occurs in adult life, particularly during tumour progression. Tumour cells undergoing epithelial-mesenchymal transition acquire the capacity to disarm the body's antitumour defences, resist apoptosis and anticancer drugs, disseminate throughout the organism, and act as a reservoir that replenishes and expands the tumour cell population. Epithelial-mesenchymal transition is therefore becoming a target of prime interest for anticancer therapy. Here, we discuss the screening and classification of compounds that affect epithelial-mesenchymal transition, highlight some compounds of particular interest, and address issues related to their clinical application.
Inglese
Marcucci, F., Stassi, G., De Maria Marchiano, R., Epithelial-mesenchymal transition: a new target in anticancer drug discovery, <<NATURE REVIEWS DRUG DISCOVERY>>, 2015; 15 (5): 311-325. [doi:10.1038/nrd.2015.13] [http://hdl.handle.net/10807/79477]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/79477
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