Knowledge on dystonia has greatly improved recently, because of a renewed effort in understanding its cause, pathophysiology, and clinical characterization. Different drug classes traditionally have been used for the symptomatic treatment of dystonia, more recently surpassed by the introduction of botulinum neurotoxins and deep brain stimulation. No curative or disease-modifying treatments are available. Recent knowledge regarding the pathophysiology of inherited dystonias is highlighting new potential treatment strategies. We review therapeutic advances in dystonia that have been published over the last 3 years, particularly regarding oral medications, local injections of botulinum neurotoxins, deep brain stimulation, and transcranial or epidural brain stimulations. We discuss evidence of efficacy, highlight recent advances, and focus on key areas under development.

Albanese, A., Romito, L. M. A., Calandrella, D., Therapeutic advances in dystonia, <<MOVEMENT DISORDERS>>, 2016; 30 (11): 1547-1556. [doi:10.1002/mds.26384] [http://hdl.handle.net/10807/79249]

Therapeutic advances in dystonia

Albanese, Alberto
Primo
;
Romito, Luigi Michele Antonio
Secondo
;
2015

Abstract

Knowledge on dystonia has greatly improved recently, because of a renewed effort in understanding its cause, pathophysiology, and clinical characterization. Different drug classes traditionally have been used for the symptomatic treatment of dystonia, more recently surpassed by the introduction of botulinum neurotoxins and deep brain stimulation. No curative or disease-modifying treatments are available. Recent knowledge regarding the pathophysiology of inherited dystonias is highlighting new potential treatment strategies. We review therapeutic advances in dystonia that have been published over the last 3 years, particularly regarding oral medications, local injections of botulinum neurotoxins, deep brain stimulation, and transcranial or epidural brain stimulations. We discuss evidence of efficacy, highlight recent advances, and focus on key areas under development.
Inglese
Albanese, A., Romito, L. M. A., Calandrella, D., Therapeutic advances in dystonia, <>, 2016; 30 (11): 1547-1556. [doi:10.1002/mds.26384] [http://hdl.handle.net/10807/79249]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/79249
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