The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.
Frisullo, G., Plantone, D., Marti, A., Iorio, R., Damato, V., Bianco, A., Nociti, V., Patanella, A. K., Batocchi, A. P., Type 1 immune response in progressive Multiple Sclerosis, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2012; 2012 (Maggio): 1-5. [doi:10.1016/j.jneuroim.2012.04.019] [http://hdl.handle.net/10807/7770]
Type 1 immune response in progressive Multiple Sclerosis
Frisullo, Giovanni;Plantone, Domenico;Marti, Alessandro;Iorio, Raffaele;Bianco, Alessandro;Nociti, Viviana;Patanella, Agata Katia;Batocchi, Anna Paola
2012
Abstract
The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.
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