The role of Ca in the prevention of hypertension is controversial, with some researches showing a lowering of blood pressure due to Ca supplementation and other studies that were not able to detect any ipo-tensive effect of this mineral. According to recent and less recent researches, Ca can lower blood pressure in two ways: - by increasing the endothelial synthesis of nitric oxide, a strong vasodilator; - by removing the misregulation of plasma renin activity in salt-sensitive subjects. As a consequence, an increase in Ca intake will be detected in the juxta-glomerular apparatus with a consequent reduction in renin and angiotensin synthesis. Renin is an enzyme, produced by kidney, that convert angiotensinogen, secreted from the liver, in angiotensin I. At pulmonary level angiotensin I is converted to angiotensin II by angiontensin-converting enzyme (ACE). Angiotensin II determines a blood vessel contraction and an increase in blood pressure.

Rossi, F., The effect of dietary calcium on hypertension., in Victor R. Preed, V. R. P. (ed.), Calcium: chemistry, analysis, function and effects, Royal Society of Chemistry, London 2015: 509- 518 [http://hdl.handle.net/10807/76303]

The effect of dietary calcium on hypertension.

Rossi, Filippo
Primo
2015

Abstract

The role of Ca in the prevention of hypertension is controversial, with some researches showing a lowering of blood pressure due to Ca supplementation and other studies that were not able to detect any ipo-tensive effect of this mineral. According to recent and less recent researches, Ca can lower blood pressure in two ways: - by increasing the endothelial synthesis of nitric oxide, a strong vasodilator; - by removing the misregulation of plasma renin activity in salt-sensitive subjects. As a consequence, an increase in Ca intake will be detected in the juxta-glomerular apparatus with a consequent reduction in renin and angiotensin synthesis. Renin is an enzyme, produced by kidney, that convert angiotensinogen, secreted from the liver, in angiotensin I. At pulmonary level angiotensin I is converted to angiotensin II by angiontensin-converting enzyme (ACE). Angiotensin II determines a blood vessel contraction and an increase in blood pressure.
Inglese
Calcium: chemistry, analysis, function and effects
978-1-84973-887-3
Royal Society of Chemistry
Rossi, F., The effect of dietary calcium on hypertension., in Victor R. Preed, V. R. P. (ed.), Calcium: chemistry, analysis, function and effects, Royal Society of Chemistry, London 2015: 509- 518 [http://hdl.handle.net/10807/76303]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/76303
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