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EnglishThe role of Ca in the prevention of hypertension is controversial, with some researches showing a lowering of blood pressure due to Ca supplementation and other studies that were not able to detect any ipo-tensive effect of this mineral. According to recent and less recent researches, Ca can lower blood pressure in two ways: - by increasing the endothelial synthesis of nitric oxide, a strong vasodilator; - by removing the misregulation of plasma renin activity in salt-sensitive subjects. As a consequence, an increase in Ca intake will be detected in the juxta-glomerular apparatus with a consequent reduction in renin and angiotensin synthesis. Renin is an enzyme, produced by kidney, that convert angiotensinogen, secreted from the liver, in angiotensin I. At pulmonary level angiotensin I is converted to angiotensin II by angiontensin-converting enzyme (ACE). Angiotensin II determines a blood vessel contraction and an increase in blood pressure.
| Autori: | |
| Titolo: | The effect of dietary calcium on hypertension. |
| Data di pubblicazione: | 2015 |
| Abstract: | The role of Ca in the prevention of hypertension is controversial, with some researches showing a lowering of blood pressure due to Ca supplementation and other studies that were not able to detect any ipo-tensive effect of this mineral. According to recent and less recent researches, Ca can lower blood pressure in two ways: - by increasing the endothelial synthesis of nitric oxide, a strong vasodilator; - by removing the misregulation of plasma renin activity in salt-sensitive subjects. As a consequence, an increase in Ca intake will be detected in the juxta-glomerular apparatus with a consequent reduction in renin and angiotensin synthesis. Renin is an enzyme, produced by kidney, that convert angiotensinogen, secreted from the liver, in angiotensin I. At pulmonary level angiotensin I is converted to angiotensin II by angiontensin-converting enzyme (ACE). Angiotensin II determines a blood vessel contraction and an increase in blood pressure. |
| Lingua: | Inglese |
| Titolo del libro: | Calcium: chemistry, analysis, function and effects |
| Editore: | Royal Society of Chemistry |
| ISBN: | 978-1-84973-887-3 |
| Citazione: | Rossi, F., The effect of dietary calcium on hypertension., in Victor R. Preed, V. R. P. (ed.), Calcium: chemistry, analysis, function and effects, Royal Society of Chemistry, London 2015: 509- 518 [http://hdl.handle.net/10807/76303] |
| Appare nelle tipologie: | In libro con curatela: Capitolo o saggio; Prefazione/Postfazione; Breve introduzione; Schede di catalogo, repertorio o corpus |
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