Poor responders to clopidogrel have low levels of circulating active metabolite. However, in vitro experiments have shown that blood platelets from poor responders are fully inhibited by the active metabolite of this prodrug. Impaired platelet inhibition reflects inadequate plasma levels of active metabolites, and not differences in platelet P2Y12 receptor function.
Patrono, C., The P2Y12 receptor: no active metabolite, no party, <<NATURE REVIEWS. CARDIOLOGY>>, 2009; 6 (4): 271-272. [doi:10.1038/nrcardio.2009.29] [http://hdl.handle.net/10807/7498]
The P2Y12 receptor: no active metabolite, no party
Patrono, Carlo
2009
Abstract
Poor responders to clopidogrel have low levels of circulating active metabolite. However, in vitro experiments have shown that blood platelets from poor responders are fully inhibited by the active metabolite of this prodrug. Impaired platelet inhibition reflects inadequate plasma levels of active metabolites, and not differences in platelet P2Y12 receptor function.
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