Prolonged cold ischemia time, the period from the start of perfusion with cold preservation fluid after cessation of circulation due to arterial clamping until transplantation in the recipient, could induce epithelial-to-mesenchymal transition (EMT) in renal tubular cells, a process associated with chronic graft damage. In this context, everolimus (EVE) and sulodexide (SUL) could potentially slow down this process.

Zaza, G., Masola, V., Granata, S., Bellin, G., Dalla Gassa, A., Onisto, M., Gambaro, G., Lupo, A., Sulodexide alone or in combination with low doses of everolimus inhibits the hypoxia-mediated epithelial to mesenchymal transition in human renal proximal tubular cells, <<JN. JOURNAL OF NEPHROLOGY>>, 2015; 28 (4): 431-440. [doi:10.1007/s40620-015-0216-y] [http://hdl.handle.net/10807/72376]

Sulodexide alone or in combination with low doses of everolimus inhibits the hypoxia-mediated epithelial to mesenchymal transition in human renal proximal tubular cells

M; Gambaro;
2015

Abstract

Prolonged cold ischemia time, the period from the start of perfusion with cold preservation fluid after cessation of circulation due to arterial clamping until transplantation in the recipient, could induce epithelial-to-mesenchymal transition (EMT) in renal tubular cells, a process associated with chronic graft damage. In this context, everolimus (EVE) and sulodexide (SUL) could potentially slow down this process.
Inglese
Zaza, G., Masola, V., Granata, S., Bellin, G., Dalla Gassa, A., Onisto, M., Gambaro, G., Lupo, A., Sulodexide alone or in combination with low doses of everolimus inhibits the hypoxia-mediated epithelial to mesenchymal transition in human renal proximal tubular cells, <<JN. JOURNAL OF NEPHROLOGY>>, 2015; 28 (4): 431-440. [doi:10.1007/s40620-015-0216-y] [http://hdl.handle.net/10807/72376]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/72376
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