Approximately 1-9 % of all head and neck squamous cell carcinomas are neck metastases from clinically undetectable primary tumors. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are proven carcinogenic factors that are associated with oropharyngeal squamous cell carcinoma and nasopharyngeal carcinoma, respectively. In the present study, we evaluated the prevalence of these viruses in neck metastases from unknown primary squamous cell carcinoma.
Bussu, F., Sali, M., Gallus, R., Petrone, G., Autorino, R., Santangelo, R., Pandolfini, M., Miccichè, F., Delogu, G., Almadori, G., Galli, J., Sanguinetti, M., Rindi, G., Tommasino, M., Valentini, V., Paludetti, G., HPV and EBV Infections in Neck Metastases from Occult Primary Squamous Cell Carcinoma: Another Virus-Related Neoplastic Disease in the Head and Neck Region, <<ANNALS OF SURGICAL ONCOLOGY>>, 2015; 22 Suppl 3 (Agosto): 979-984. [doi:10.1245/s10434-015-4808-5] [http://hdl.handle.net/10807/72318]
HPV and EBV Infections in Neck Metastases from Occult Primary Squamous Cell Carcinoma: Another Virus-Related Neoplastic Disease in the Head and Neck Region
Bussu, Francesco;Sali, Michela;Gallus, Roberto;Petrone, Gianluigi;Autorino, Rosa;Santangelo, Rosaria;Pandolfini, Manlio;Delogu, Giovanni;Galli, Jacopo;Sanguinetti, Maurizio;Rindi, Guido;Tommasino, Massimo;Valentini, Vincenzo;Paludetti, Gaetano
2015
Abstract
Approximately 1-9 % of all head and neck squamous cell carcinomas are neck metastases from clinically undetectable primary tumors. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are proven carcinogenic factors that are associated with oropharyngeal squamous cell carcinoma and nasopharyngeal carcinoma, respectively. In the present study, we evaluated the prevalence of these viruses in neck metastases from unknown primary squamous cell carcinoma.
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