Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.

Evoli, A., Tsonis, A., Zisimopoulou, P., Matsigkou, E., Lazaridis, K., Tzartos, J., Zouvelou, V., Mantegazza, R., Antozzi, C., Andreetta, F., Deymeer, F., Saruhan Direskeneli, G., Durmus, H., Brenner, T., Vaknin, A., Behin, A., Berrih Aknin, S., Sharshar, T., De Baets, M., Martinez Martinez, P., Losen, M., Zamba Papanicolaou, E., Kleopa, K., Kyriakides, T., Kostera Pruszczyk, A., Szczudlik, P., Szyluk, B., Lavrnic, D., Basta, I., Peric, S., Tallaksen, C., Maniaol, A., Casasnovas Pons, C., Pitha, J., Jakubíkova, M., Hanisch, F., Tzartos, S., MuSK autoantibodies in myasthenia gravis detected by cell based assay-A multinational study, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2015; 284 (Luglio): 10-17. [doi:10.1016/j.jneuroim.2015.04.015.] [http://hdl.handle.net/10807/71472]

MuSK autoantibodies in myasthenia gravis detected by cell based assay-A multinational study

Evoli, Amelia;
2015

Abstract

Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.
Inglese
Evoli, A., Tsonis, A., Zisimopoulou, P., Matsigkou, E., Lazaridis, K., Tzartos, J., Zouvelou, V., Mantegazza, R., Antozzi, C., Andreetta, F., Deymeer, F., Saruhan Direskeneli, G., Durmus, H., Brenner, T., Vaknin, A., Behin, A., Berrih Aknin, S., Sharshar, T., De Baets, M., Martinez Martinez, P., Losen, M., Zamba Papanicolaou, E., Kleopa, K., Kyriakides, T., Kostera Pruszczyk, A., Szczudlik, P., Szyluk, B., Lavrnic, D., Basta, I., Peric, S., Tallaksen, C., Maniaol, A., Casasnovas Pons, C., Pitha, J., Jakubíkova, M., Hanisch, F., Tzartos, S., MuSK autoantibodies in myasthenia gravis detected by cell based assay-A multinational study, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2015; 284 (Luglio): 10-17. [doi:10.1016/j.jneuroim.2015.04.015.] [http://hdl.handle.net/10807/71472]
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