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EnglishAbstract The distinction between myasthenia gravis and Lambert-Eaton myasthenic syndrome is based on clinical, neurophysiological and immunological features. We hereby report two cases with a clinical diagnosis of myasthenia gravis and neurophysiological features consistent with a pre-synaptic neuromuscular transmission defect. Both patients had increased anti-acetylcholine receptor antibody titres and showed a good response to cholinesterase inhibitors, along with a >100% facilitation of the compound muscle action potential on electrophysiological studies. We provide a review of English literature studies on co-existing features of myasthenia gravis and Lambert-Eaton myasthenic syndrome, and discuss diagnostic controversies.
| Autori: | |
| Titolo: | Myasthenia gravis with presynaptic neurophysiological signs: Two case reports and literature review |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.nmd.2015.04.012. |
| Data di pubblicazione: | 2015 |
| Abstract: | Abstract The distinction between myasthenia gravis and Lambert-Eaton myasthenic syndrome is based on clinical, neurophysiological and immunological features. We hereby report two cases with a clinical diagnosis of myasthenia gravis and neurophysiological features consistent with a pre-synaptic neuromuscular transmission defect. Both patients had increased anti-acetylcholine receptor antibody titres and showed a good response to cholinesterase inhibitors, along with a >100% facilitation of the compound muscle action potential on electrophysiological studies. We provide a review of English literature studies on co-existing features of myasthenia gravis and Lambert-Eaton myasthenic syndrome, and discuss diagnostic controversies. |
| Lingua: | Inglese |
| Rivista: | |
| Citazione: | Evoli, A., Alboini, P. E., Damato, V., Iorio, R., Luigetti, M., Myasthenia gravis with presynaptic neurophysiological signs: Two case reports and literature review, <<NEUROMUSCULAR DISORDERS>>, 2015; 25 (8): 646-650. [doi:10.1016/j.nmd.2015.04.012.] [http://hdl.handle.net/10807/71455] |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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