CTLA-4 Ig as an effective treatment in a patient with type I diabetes mellitus and seropositive rheumatoid arthritis

Fedele, Anna Laura; Alivernini, Stefano; Gremese, Elisa; Ferraccioli, Gianfranco

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We describe a patient suffering from seropositive rheumatoid arthritis (RA) and type I diabetes mellitus (T1DM), who achieved a good EULAR response together with an improvement of the glycemic profile under treatment with CTLA-4 Ig. A close association is known to exist between T1DM and RA, and CTLA-4 exon 1 polymorphism has been associated to RA with coexisting autoimmune endocrinopathies. The possible common genetic background and the potential role of CTLA-4 Ig in the early phases of T1DM, could be considered in the therapeutic interventions in RA patients with type 1 diabetes.

Autori:	Fedele, Anna Laura Alivernini, Stefano Gremese, Elisa Ferraccioli, Gianfranco
Titolo:	CTLA-4 Ig as an effective treatment in a patient with type I diabetes mellitus and seropositive rheumatoid arthritis
Data di pubblicazione:	2015
Abstract:	We describe a patient suffering from seropositive rheumatoid arthritis (RA) and type I diabetes mellitus (T1DM), who achieved a good EULAR response together with an improvement of the glycemic profile under treatment with CTLA-4 Ig. A close association is known to exist between T1DM and RA, and CTLA-4 exon 1 polymorphism has been associated to RA with coexisting autoimmune endocrinopathies. The possible common genetic background and the potential role of CTLA-4 Ig in the early phases of T1DM, could be considered in the therapeutic interventions in RA patients with type 1 diabetes.
Lingua:	Inglese
Rivista:	CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Citazione:	Fedele, A. L., Alivernini, S., Gremese, E., Ferraccioli, G., CTLA-4 Ig as an effective treatment in a patient with type I diabetes mellitus and seropositive rheumatoid arthritis, <<CLINICAL AND EXPERIMENTAL RHEUMATOLOGY>>, 2015; (Novembre): N/A-N/A [http://hdl.handle.net/10807/71454]
Appare nelle tipologie:	Articolo in rivista, Nota a sentenza

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