Dicarboxylic acids are natural products with the potential of being an alternate dietary source of energy. We aimed to evaluate the effect of sebacic acid (a 10-carbon dicarboxylic acid; C10) ingestion on postprandial glycemia and glucose rate of appearance (Ra) in healthy and type 2 diabetic subjects. Furthermore, the effect of C10 on insulin-mediated glucose uptake and on GLUT4 expression was assessed in L6 muscle cells in vitro.
Iaconelli, A., Gastaldelli, A., Chiellini, C., Gniuli, D., Favuzzi, A. M. R., Binnert, C., Macé, K., Mingrone, G., Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes, <<DIABETES CARE>>, 2010; 33 (11): 2327-2332. [doi:10.2337/dc10-0663] [http://hdl.handle.net/10807/7142]
Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes
Iaconelli, Amerigo;Favuzzi, Angela Maria Rita;Mingrone, Geltrude
2010
Abstract
Dicarboxylic acids are natural products with the potential of being an alternate dietary source of energy. We aimed to evaluate the effect of sebacic acid (a 10-carbon dicarboxylic acid; C10) ingestion on postprandial glycemia and glucose rate of appearance (Ra) in healthy and type 2 diabetic subjects. Furthermore, the effect of C10 on insulin-mediated glucose uptake and on GLUT4 expression was assessed in L6 muscle cells in vitro.
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