BACKGROUND: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. METHODS: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis. RESULTS: We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5-77.8) pg/mL and 43.89 (37.5-50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95% CI, 2.09-15.29]. CONCLUSIONS: We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.

Biscetti, F., Straface, G., Porreca, C. F., Bertoletti Giovan, B., Vincenzoni, C., Snider, F., Stigliano, E., Arena, V., Angelini, F., Pecorini, G., Bianchi, A., Landolfi, R., Flex, A., Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis., <<CARDIOVASCULAR DIABETOLOGY>>, 2015; 2015 (Ottobre): 139-145. [doi:10.1186/s12933-015-0301-5] [http://hdl.handle.net/10807/70510]

Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.

Biscetti, Federico;Straface, Giuseppe;Porreca, Carlo Filippo;Vincenzoni, Claudio;Snider, Francesco;Stigliano, Egidio;Arena, Vincenzo;Angelini, Flavia;Pecorini, Giovanni;Bianchi, Antonio;Landolfi, Raffaele;Flex, Andrea
2015

Abstract

BACKGROUND: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. METHODS: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis. RESULTS: We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5-77.8) pg/mL and 43.89 (37.5-50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95% CI, 2.09-15.29]. CONCLUSIONS: We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.
Inglese
Biscetti, F., Straface, G., Porreca, C. F., Bertoletti Giovan, B., Vincenzoni, C., Snider, F., Stigliano, E., Arena, V., Angelini, F., Pecorini, G., Bianchi, A., Landolfi, R., Flex, A., Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis., <>, 2015; 2015 (Ottobre): 139-145. [doi:10.1186/s12933-015-0301-5] [http://hdl.handle.net/10807/70510]
File in questo prodotto:
File Dimensione Formato  
Cardiovasc Diabetol.pdf

accesso aperto

Tipologia file ?: Versione Editoriale (PDF)
Licenza: Non specificato
Dimensione 637.44 kB
Formato Adobe PDF
637.44 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/70510
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 14
social impact