In post-menopausal period vulvo-vaginal atrophy (VVA)-related symptoms may seriously affect women's quality of life. Hormonal replacement therapy effectively relieves these symptoms but it is not always safe or accepted, and a non-hormonal treatment is often needed instead. Over a period of 12 weeks, we tested the effect of a twice-a-week vulvo-vaginal application of a hyaluronic acid, AC collagen, isoflavones and vitamins-based cream (Perilei Pausa®) on 35 women in post-menopausal period, reporting VVA-related symptoms. After 12 weeks of treatment with Perilei Pausa® a significant improvement in vaginal dryness, vulvo-vaginal itching, dyspareunia (P < 0.001), dysuria (P = 0.02), nocturia (P = 0.009) and pollakiuria (P = 0.005) was reported by the women. Colposcopical score assessing the intensity of atrophic colpitis, cervico-vaginal paleness and petechiae was also reduced (P = 0.037, P = 0.016 and P = 0.032, respectively). No significant difference in terms of maturation value of cervico-vaginal epithelium was observed. In conclusion, Perilei Pausa® may represent an effective and safe alternative treatment of symptomatic VVA in post-menopausal women.

Tersigni, C., Di Simone, N., Cianfrini, F., Russo, R. M., Moruzzi, M. C., Amar, I. D., Scambia, G., Villa, P., Non-hormonal treatment of vulvo-vaginal atrophy-related symptoms in post-menopausal women, <<JOURNAL OF OBSTETRICS AND GYNAECOLOGY>>, 2015; 35 (Novembre): 835-838. [doi:10.3109/01443615.2015.1014326] [http://hdl.handle.net/10807/70416]

Non-hormonal treatment of vulvo-vaginal atrophy-related symptoms in post-menopausal women

Tersigni, Chiara;Di Simone, Nicoletta;Cianfrini, Federica;Russo, Raffaella Maria;Moruzzi, Maria Cristina;Amar, Inbal Dona;Scambia, Giovanni;Villa, Paola
2015

Abstract

In post-menopausal period vulvo-vaginal atrophy (VVA)-related symptoms may seriously affect women's quality of life. Hormonal replacement therapy effectively relieves these symptoms but it is not always safe or accepted, and a non-hormonal treatment is often needed instead. Over a period of 12 weeks, we tested the effect of a twice-a-week vulvo-vaginal application of a hyaluronic acid, AC collagen, isoflavones and vitamins-based cream (Perilei Pausa®) on 35 women in post-menopausal period, reporting VVA-related symptoms. After 12 weeks of treatment with Perilei Pausa® a significant improvement in vaginal dryness, vulvo-vaginal itching, dyspareunia (P < 0.001), dysuria (P = 0.02), nocturia (P = 0.009) and pollakiuria (P = 0.005) was reported by the women. Colposcopical score assessing the intensity of atrophic colpitis, cervico-vaginal paleness and petechiae was also reduced (P = 0.037, P = 0.016 and P = 0.032, respectively). No significant difference in terms of maturation value of cervico-vaginal epithelium was observed. In conclusion, Perilei Pausa® may represent an effective and safe alternative treatment of symptomatic VVA in post-menopausal women.
Inglese
Tersigni, C., Di Simone, N., Cianfrini, F., Russo, R. M., Moruzzi, M. C., Amar, I. D., Scambia, G., Villa, P., Non-hormonal treatment of vulvo-vaginal atrophy-related symptoms in post-menopausal women, <<JOURNAL OF OBSTETRICS AND GYNAECOLOGY>>, 2015; 35 (Novembre): 835-838. [doi:10.3109/01443615.2015.1014326] [http://hdl.handle.net/10807/70416]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/70416
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