Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.

Delahaye Sourdeix, M., Oliver, J., Timofeeva, M., Gaborieau, V., Johansson, M., Chabrier, A., Wozniak, M., Brenner, D., Vallée, M., Anantharaman, D., Lagiou, P., Holcátová, I., Richiardi, L., Kjaerheim, K., Agudo, A., Castellsagué, X., Macfarlane, T., Barzan, L., Canova, C., Thakker, N., Conway, D., Znaor, A., Healy, C., Ahrens, W., Zaridze, D., Szeszenia Dabrowska, N., Lissowska, J., Fabianova, E., Mates, I., Bencko, V., Foretova, L., Janout, V., Curado, M., Koifman, S., Menezes, A., Wünsch Filho, V., Eluf Neto, J., Boffetta, P., Garrote, L., Serraino, D., Lener, M., Jaworowska, E., Lubiński, J., Boccia, S., Rajkumar, T., Samant, T., Mahimkar, M., Matsuo, K., Franceschi, S., Byrnes, G., Brennan, P., Mckay, J., The 12p13.33/RAD52 Locus and Genetic Susceptibility to Squamous Cell Cancers of Upper Aerodigestive Tract, <<PLOS ONE>>, 2015; 10 (3): e0117639-e0117639. [doi:10.1371/journal.pone.0117639] [http://hdl.handle.net/10807/70404]

The 12p13.33/RAD52 Locus and Genetic Susceptibility to Squamous Cell Cancers of Upper Aerodigestive Tract

Boccia, Stefania;
2015

Abstract

Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
Inglese
Delahaye Sourdeix, M., Oliver, J., Timofeeva, M., Gaborieau, V., Johansson, M., Chabrier, A., Wozniak, M., Brenner, D., Vallée, M., Anantharaman, D., Lagiou, P., Holcátová, I., Richiardi, L., Kjaerheim, K., Agudo, A., Castellsagué, X., Macfarlane, T., Barzan, L., Canova, C., Thakker, N., Conway, D., Znaor, A., Healy, C., Ahrens, W., Zaridze, D., Szeszenia Dabrowska, N., Lissowska, J., Fabianova, E., Mates, I., Bencko, V., Foretova, L., Janout, V., Curado, M., Koifman, S., Menezes, A., Wünsch Filho, V., Eluf Neto, J., Boffetta, P., Garrote, L., Serraino, D., Lener, M., Jaworowska, E., Lubiński, J., Boccia, S., Rajkumar, T., Samant, T., Mahimkar, M., Matsuo, K., Franceschi, S., Byrnes, G., Brennan, P., Mckay, J., The 12p13.33/RAD52 Locus and Genetic Susceptibility to Squamous Cell Cancers of Upper Aerodigestive Tract, <<PLOS ONE>>, 2015; 10 (3): e0117639-e0117639. [doi:10.1371/journal.pone.0117639] [http://hdl.handle.net/10807/70404]
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