The epithelial-mesenchymal transition (EMT) is a morphogenetic process that results in a loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. First described in embryogenesis, the EMT has been recently implicated in carcinogenesis and tumor progression. In addition, recent evidence has shown that stem-like cancer cells present the hallmarks of the EMT. Some of the molecular mechanisms related to the interrelationships between cancer pathophysiology and the EMT are well-defined. Nevertheless, the precise molecular mechanism by which epithelial cancer cells acquire the mesenchymal phenotype remains largely unknown. This review focuses on various proteomic strategies with the goal of better understanding the physiological and pathological mechanisms of the EMT process

Scatena, R., Isgro', M. A., Bottoni, P., The epithelial–mesenchymal transition in cancer: a potential critical topic for translational proteomic research, <<EXPERT REVIEW OF PROTEOMICS>>, 2016; 2016 (Gennaio): 115-133. [doi:10.1586/14789450.2016.1112742] [http://hdl.handle.net/10807/70090]

The epithelial–mesenchymal transition in cancer: a potential critical topic for translational proteomic research

Scatena, Roberto;Isgro', Maria Antonietta;Bottoni, Patrizia
2015

Abstract

The epithelial-mesenchymal transition (EMT) is a morphogenetic process that results in a loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. First described in embryogenesis, the EMT has been recently implicated in carcinogenesis and tumor progression. In addition, recent evidence has shown that stem-like cancer cells present the hallmarks of the EMT. Some of the molecular mechanisms related to the interrelationships between cancer pathophysiology and the EMT are well-defined. Nevertheless, the precise molecular mechanism by which epithelial cancer cells acquire the mesenchymal phenotype remains largely unknown. This review focuses on various proteomic strategies with the goal of better understanding the physiological and pathological mechanisms of the EMT process
Inglese
Scatena, R., Isgro', M. A., Bottoni, P., The epithelial–mesenchymal transition in cancer: a potential critical topic for translational proteomic research, <<EXPERT REVIEW OF PROTEOMICS>>, 2016; 2016 (Gennaio): 115-133. [doi:10.1586/14789450.2016.1112742] [http://hdl.handle.net/10807/70090]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/70090
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