Presbycusis is the most common cause of hearing loss in aged subjects, reducing individual's communicative skills. Age related hearing loss can be defined as a progressive, bilateral, symmetrical hearing loss due to age related degeneration and it can be considered a multifactorial complex disorder, with both environmental and genetic factors contributing to the aetiology of the disease. The decline in hearing sensitivity caused by ageing is related to the damage at different levels of the auditory system (central and peripheral). Histologically, the aged cochlea shows degeneration of the stria vascularis, the sensorineural epithelium, and neurons of the central auditory pathways. The mechanisms responsible for age-associated hearing loss are still incompletely characterized. This work aims to give a broad overview of the scientific findings related to presbycusis, focusing mainly on experimental studies in animal models.
Fetoni, A. R., Picciotti, P. M., Paludetti, G., Troiani, D., Pathogenesis of presbycusis in animal models: a review, <<EXPERIMENTAL GERONTOLOGY>>, 2011; 46 (6): 413-425. [doi:10.1016/j.exger.2010.12.003] [https://hdl.handle.net/10807/7001]
Pathogenesis of presbycusis in animal models: a review
Fetoni, Anna Rita;Picciotti, Pasqualina Maria;Paludetti, Gaetano;Troiani, Diana
2011
Abstract
Presbycusis is the most common cause of hearing loss in aged subjects, reducing individual's communicative skills. Age related hearing loss can be defined as a progressive, bilateral, symmetrical hearing loss due to age related degeneration and it can be considered a multifactorial complex disorder, with both environmental and genetic factors contributing to the aetiology of the disease. The decline in hearing sensitivity caused by ageing is related to the damage at different levels of the auditory system (central and peripheral). Histologically, the aged cochlea shows degeneration of the stria vascularis, the sensorineural epithelium, and neurons of the central auditory pathways. The mechanisms responsible for age-associated hearing loss are still incompletely characterized. This work aims to give a broad overview of the scientific findings related to presbycusis, focusing mainly on experimental studies in animal models.
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| dc.authority.academicField2000 | Settore MED/32 - AUDIOLOGIA | en |
| dc.authority.ancejournal | EXPERIMENTAL GERONTOLOGY | en |
| dc.authority.erc2011 | Health services, health care research | en |
| dc.authority.people | Fetoni, Anna Rita | it |
| dc.authority.people | Picciotti, Pasqualina Maria | it |
| dc.authority.people | Paludetti, Gaetano | it |
| dc.authority.people | Troiani, Diana | it |
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| dc.date.issued | 2011 | - |
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| dc.description.abstracteng | Presbycusis is the most common cause of hearing loss in aged subjects, reducing individual's communicative skills. Age related hearing loss can be defined as a progressive, bilateral, symmetrical hearing loss due to age related degeneration and it can be considered a multifactorial complex disorder, with both environmental and genetic factors contributing to the aetiology of the disease. The decline in hearing sensitivity caused by ageing is related to the damage at different levels of the auditory system (central and peripheral). Histologically, the aged cochlea shows degeneration of the stria vascularis, the sensorineural epithelium, and neurons of the central auditory pathways. The mechanisms responsible for age-associated hearing loss are still incompletely characterized. This work aims to give a broad overview of the scientific findings related to presbycusis, focusing mainly on experimental studies in animal models. | - |
| dc.description.allpeople | Fetoni, Anna Rita; Picciotti, Pasqualina Maria; Paludetti, Gaetano; Troiani, Diana | - |
| dc.description.allpeopleoriginal | Fetoni, Anna Rita; Picciotti, Pasqualina Maria; Paludetti, Gaetano; Troiani, Diana | it |
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| dc.identifier.citation | Fetoni, A. R., Picciotti, P. M., Paludetti, G., Troiani, D., Pathogenesis of presbycusis in animal models: a review, < |
en |
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| dc.subject.keywords | Animals | en |
| dc.subject.keywords | Auditory Pathways | en |
| dc.subject.keywords | Cochlea | en |
| dc.subject.keywords | Gerbillinae | en |
| dc.subject.keywords | Mice | en |
| dc.subject.keywords | Models, Animal | en |
| dc.subject.keywords | Presbycusis | en |
| dc.subject.keywords | Rats | en |
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| dc.subject.singlekeyword | Models | * |
| dc.subject.singlekeyword | Animal | * |
| dc.subject.singlekeyword | Presbycusis | * |
| dc.subject.singlekeyword | Rats | * |
| dc.title | Pathogenesis of presbycusis in animal models: a review | en |
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| isi.contributor.name | Pasqualina M. | - |
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| isi.description.abstracteng | Presbycusis is the most common cause of hearing loss in aged subjects, reducing individual's communicative skills. Age related hearing loss can be defined as a progressive, bilateral, symmetrical hearing loss due to age related degeneration and it can be considered a multifactorial complex disorder, with both environmental and genetic factors contributing to the aetiology of the disease.The decline in hearing sensitivity caused by ageing is related to the damage at different levels of the auditory system (central and peripheral). Histologically, the aged cochlea shows degeneration of the stria vascularis, the sensorineural epithelium, and neurons of the central auditory pathways. The mechanisms responsible for age-associated hearing loss are still incompletely characterized.This work aims to give a broad overview of the scientific findings related to presbycusis, focusing; mainly on experimental studies in animal models. (C) 2011 Elsevier Inc. All rights reserved. | * |
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| scopus.date.issued | 2011 | * |
| scopus.description.abstracteng | Presbycusis is the most common cause of hearing loss in aged subjects, reducing individual's communicative skills. Age related hearing loss can be defined as a progressive, bilateral, symmetrical hearing loss due to age related degeneration and it can be considered a multifactorial complex disorder, with both environmental and genetic factors contributing to the aetiology of the disease. The decline in hearing sensitivity caused by ageing is related to the damage at different levels of the auditory system (central and peripheral). Histologically, the aged cochlea shows degeneration of the stria vascularis, the sensorineural epithelium, and neurons of the central auditory pathways. The mechanisms responsible for age-associated hearing loss are still incompletely characterized. This work aims to give a broad overview of the scientific findings related to presbycusis, focusing mainly on experimental studies in animal models. © 2011 Elsevier Inc. | * |
| scopus.description.allpeopleoriginal | Fetoni A.R.; Picciotti P.M.; Paludetti G.; Troiani D. | * |
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| scopus.subject.keywords | Ageing; ARHL; Cochlea; Hearing loss; MDNA; ROS; SGNs; Stria vascularis; VEGF; | * |
| scopus.title | Pathogenesis of presbycusis in animal models: A review | * |
| scopus.titleeng | Pathogenesis of presbycusis in animal models: A review | * |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza | |
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