Coexistence of primary hyperparathyroidism and acute pancreatitis has widely been reported in literature, but a causal relationship remains controversial. A case of acute pancreatitis as a first symptom of primary hyperparathyroidism with severe hypercalcemia is reported. In this patient a reduction of serum calcium level was obtained with medical therapy and resulted in the resolution of acute pancreatitis symptoms within 10 days. At the same time a parathyroid adenoma was clinically identified and elective parathyroidectomy was performed with complete normalization of intact parathyroid hormone and serum calcium level. At three-year follow-up, no recurrence or complications of pancreatitis were documented. The presented case suggests a cause and effect relationship between acute pancreatitis and severe hypercalcemia which should be kept in mind in the differential diagnosis of non-biliary, non-alcoholic acute pancreatitis. Reduction of hypercalcemia with medical treatment can represent a good chance for elective surgical neck exploration.

Biondi, A., Persiani, R., Marchese, M., Cananzi, F. C. M., D'Ugo, D., Acute pancreatitis associated with primary hyperparathyroidism, <<UPDATES IN SURGERY>>, 2010; 63 (2): 135-138. [doi:10.1007/s13304-011-0048-9] [http://hdl.handle.net/10807/6993]

Acute pancreatitis associated with primary hyperparathyroidism

Biondi, Alberto;Persiani, Roberto;Marchese, Manuela;Cananzi, Ferdinando Carlo Maria;D'Ugo, Domenico
2011

Abstract

Coexistence of primary hyperparathyroidism and acute pancreatitis has widely been reported in literature, but a causal relationship remains controversial. A case of acute pancreatitis as a first symptom of primary hyperparathyroidism with severe hypercalcemia is reported. In this patient a reduction of serum calcium level was obtained with medical therapy and resulted in the resolution of acute pancreatitis symptoms within 10 days. At the same time a parathyroid adenoma was clinically identified and elective parathyroidectomy was performed with complete normalization of intact parathyroid hormone and serum calcium level. At three-year follow-up, no recurrence or complications of pancreatitis were documented. The presented case suggests a cause and effect relationship between acute pancreatitis and severe hypercalcemia which should be kept in mind in the differential diagnosis of non-biliary, non-alcoholic acute pancreatitis. Reduction of hypercalcemia with medical treatment can represent a good chance for elective surgical neck exploration.
2011
Inglese
Biondi, A., Persiani, R., Marchese, M., Cananzi, F. C. M., D'Ugo, D., Acute pancreatitis associated with primary hyperparathyroidism, <<UPDATES IN SURGERY>>, 2010; 63 (2): 135-138. [doi:10.1007/s13304-011-0048-9] [http://hdl.handle.net/10807/6993]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/6993
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