IRIS PubliCatt
PubliCatt è il repository istituzionale ad accesso aperto dell'Università Cattolica del Sacro Cuore, dove gli utenti autorizzati afferenti all'Ateneo provvedono direttamente e autonomamente a depositare e a rendere visibili le proprie pubblicazioni, inserendo i dati descrittivi del documento stesso ("metadati", quali il titolo, autore, abstract, etc.) e, laddove possibile, il testo della pubblicazione stessa (full-text).
PubliCatt utilizza la piattaforma IRIS (Institutional Research Information System) sviluppata da CINECA.
EnglishTo evaluate whether the age-dependence of brain plasticity correlates with the levels of proteins involved in hormone and brain functions we executed a paired associative stimulation (PAS) protocol and blood tests. We measured the PAS-induced plasticity in the primary motor cortex. Blood levels of the brain-derived neurotrophic factor (BDNF), estradiol, the insulin-like growth factor (IGF)-1, the insulin-like growth factor binding protein (IGFBP)-3, progesterone, sex hormone-binding globulin (SHBG), testosterone, and the transforming growth factor beta 1 (TGF-β1) were determined in 15 healthy men and 20 healthy women. We observed an age-related reduction of PAS-induced plasticity in females that it is not present in males. In females, PAS-induced plasticity displayed a correlation with testosterone (p = 0.006) that became a trend after the adjustment for the age effect (p = 0.078). In males, IGF-1 showed a nominally significant correlation with the PAS-induced plasticity (p = 0.043). In conclusion, we observed that hormone blood levels (testosterone in females and IGF-1 in males) may be involved in the age-dependence of brain plasticity.
Polimanti, R., Simonelli, I., Zappasodi, F., Ventriglia, M., Pellicciari, M., Benussi, L., Squitti, R., Rossini, P. M., Tecchio, F., Biological factors and age-dependence of primary motor cortex experimental plasticity, <<NEUROLOGICAL SCIENCES>>, 2015; (N/A): N/A-N/A. [doi:10.1007/s10072-015-2388-6] [http://hdl.handle.net/10807/69848]
| Autori: | ||
| Titolo: | Biological factors and age-dependence of primary motor cortex experimental plasticity | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s10072-015-2388-6 | |
| Data di pubblicazione: | 2015 | |
| Abstract: | To evaluate whether the age-dependence of brain plasticity correlates with the levels of proteins involved in hormone and brain functions we executed a paired associative stimulation (PAS) protocol and blood tests. We measured the PAS-induced plasticity in the primary motor cortex. Blood levels of the brain-derived neurotrophic factor (BDNF), estradiol, the insulin-like growth factor (IGF)-1, the insulin-like growth factor binding protein (IGFBP)-3, progesterone, sex hormone-binding globulin (SHBG), testosterone, and the transforming growth factor beta 1 (TGF-β1) were determined in 15 healthy men and 20 healthy women. We observed an age-related reduction of PAS-induced plasticity in females that it is not present in males. In females, PAS-induced plasticity displayed a correlation with testosterone (p = 0.006) that became a trend after the adjustment for the age effect (p = 0.078). In males, IGF-1 showed a nominally significant correlation with the PAS-induced plasticity (p = 0.043). In conclusion, we observed that hormone blood levels (testosterone in females and IGF-1 in males) may be involved in the age-dependence of brain plasticity. | |
| Lingua: | Inglese | |
| Rivista: | ||
| Citazione: | Polimanti, R., Simonelli, I., Zappasodi, F., Ventriglia, M., Pellicciari, M., Benussi, L., Squitti, R., Rossini, P. M., Tecchio, F., Biological factors and age-dependence of primary motor cortex experimental plasticity, <<NEUROLOGICAL SCIENCES>>, 2015; (N/A): N/A-N/A. [doi:10.1007/s10072-015-2388-6] [http://hdl.handle.net/10807/69848] | |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
File in questo prodotto:
Copyright © 2022