Botulinum toxin A inhibits neuromuscular transmission. It has become a drug with many indications. The range of clinical applications has grown to encompass several neurological and non-neurological conditions. One of the most recent achievements in the field is the observation that botulinum toxin A provides benefit in diseases of the gastrointestinal tract. Although toxin blocks cholinergic nerve endings in the autonomic nervous system, it has also been shown that it does not block non-adrenergic non-cholinergic responses mediated by nitric oxide. This has promoted further interest in using botulinum toxin A as a treatment for overactive smooth muscles and sphincters. The introduction of this therapy has made the treatment of several clinical conditions easier, in the outpatient setting, at a lower cost and without permanent complications. This review presents current data on the use of botulinum toxin A in the treatment of pathological conditions of the gastrointestinal tract.

Brisinda, G., Silvestrini, N., Bianco, G., Maria, G., Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A, <<TOXINS>>, 2015; 7 (6): 1882-1916. [doi:10.3390/toxins7061882] [http://hdl.handle.net/10807/69668]

Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A

Brisinda, Giuseppe;Silvestrini, Nicola;Bianco, Giuseppe;Maria, Giorgio
2015

Abstract

Botulinum toxin A inhibits neuromuscular transmission. It has become a drug with many indications. The range of clinical applications has grown to encompass several neurological and non-neurological conditions. One of the most recent achievements in the field is the observation that botulinum toxin A provides benefit in diseases of the gastrointestinal tract. Although toxin blocks cholinergic nerve endings in the autonomic nervous system, it has also been shown that it does not block non-adrenergic non-cholinergic responses mediated by nitric oxide. This has promoted further interest in using botulinum toxin A as a treatment for overactive smooth muscles and sphincters. The introduction of this therapy has made the treatment of several clinical conditions easier, in the outpatient setting, at a lower cost and without permanent complications. This review presents current data on the use of botulinum toxin A in the treatment of pathological conditions of the gastrointestinal tract.
Inglese
Brisinda, G., Silvestrini, N., Bianco, G., Maria, G., Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A, <<TOXINS>>, 2015; 7 (6): 1882-1916. [doi:10.3390/toxins7061882] [http://hdl.handle.net/10807/69668]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/69668
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