IRIS PubliCatt
PubliCatt è il repository istituzionale ad accesso aperto dell'Università Cattolica del Sacro Cuore, dove gli utenti autorizzati afferenti all'Ateneo provvedono direttamente e autonomamente a depositare e a rendere visibili le proprie pubblicazioni, inserendo i dati descrittivi del documento stesso ("metadati", quali il titolo, autore, abstract, etc.) e, laddove possibile, il testo della pubblicazione stessa (full-text).
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EnglishThe success of a primary percutaneous intervention (PCI) in the setting of ST elevation myocardial infarction depends on the functional and structural integrity of coronary microcirculation. Coronary microvascular dysfunction and obstruction (CMVO) occurs in up to half of patients submitted to apparently successful primary PCI and is associated to a much worse outcome. The current review summarizes the complex mechanisms responsible for CMVO, including pre-existing coronary microvascular dysfunction, and highlights the current limitations in the assessment of microvascular function. More importantly, at the light of the substantial failure of trials hitherto published on the treatment of CMVO, this review proposes a novel integrated therapeutic approach, which should overcome the limitations of previous studies.
Niccoli, G., Scalone, G., Lerman, A., Crea, F., Coronary microvascular obstruction in acute myocardial infarction, <<EUROPEAN HEART JOURNAL>>, 2015; 2015 (Settembre): N/A-N/A. [doi:10.1093/eurheartj/ehv484] [http://hdl.handle.net/10807/69167]
| Autori: | ||
| Titolo: | Coronary microvascular obstruction in acute myocardial infarction | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/eurheartj/ehv484 | |
| Data di pubblicazione: | 2015 | |
| Abstract: | The success of a primary percutaneous intervention (PCI) in the setting of ST elevation myocardial infarction depends on the functional and structural integrity of coronary microcirculation. Coronary microvascular dysfunction and obstruction (CMVO) occurs in up to half of patients submitted to apparently successful primary PCI and is associated to a much worse outcome. The current review summarizes the complex mechanisms responsible for CMVO, including pre-existing coronary microvascular dysfunction, and highlights the current limitations in the assessment of microvascular function. More importantly, at the light of the substantial failure of trials hitherto published on the treatment of CMVO, this review proposes a novel integrated therapeutic approach, which should overcome the limitations of previous studies. | |
| Lingua: | Inglese | |
| Rivista: | ||
| Citazione: | Niccoli, G., Scalone, G., Lerman, A., Crea, F., Coronary microvascular obstruction in acute myocardial infarction, <<EUROPEAN HEART JOURNAL>>, 2015; 2015 (Settembre): N/A-N/A. [doi:10.1093/eurheartj/ehv484] [http://hdl.handle.net/10807/69167] | |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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