Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.
Paneni, F., Costantino, S., Castello, L., Battista, R., Capretti, G., Chiandotto, S., D'Amario, D., Scavone, G., Villano, A., Rustighi, A., Crea, F., Pitocco, D., Lanza, G. A., Volpe, M., Del Sal, G., Lüscher, T., Cosentino, F., Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes, <<EUROPEAN HEART JOURNAL>>, 2015; 36 (13): 817-828. [doi:10.1093/eurheartj/ehu179] [http://hdl.handle.net/10807/69144]
Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes
D'Amario, Domenico;Villano, Angelo;Crea, Filippo;Pitocco, Dario;Lanza, Gaetano Antonio;Volpe, Massimo;
2015
Abstract
Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.
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