The alterations occurring in the intestinal flora during Clostridium difficile infection (CDI) may promote the translocation of Candida to the blood and the development of candidaemia. The aim of our study was to analyse clinical findings of these patients to determine the risk factors associated with the development of candidaemia subsequent to CDI. We compared 35 patients with candidaemia subsequent to CDI with 105 patients with CDI. Patients with candidaemia showed more severe infections and higher mortality. The ribotype 027 strain and vancomycin treatment at ≥1000 mg/day were prevalent in patients developing candidaemia. CDI may predispose to the translocation of Candida.

Russo, A., Falcone, M., Fantoni, M., Murri, R., Masucci, L., Carfagna, P., Ghezzi, M., Posteraro, B., Sanguinetti, M., Venditti, M., Risk factors and clinical outcomes of candidaemia in patients treated for Clostridium difficile infection, <<CLINICAL MICROBIOLOGY AND INFECTION>>, 2015; 21 (5): 493.e1-493.e1-4. [doi:10.1016/j.cmi.2014.12.024] [http://hdl.handle.net/10807/69052]

Risk factors and clinical outcomes of candidaemia in patients treated for Clostridium difficile infection

Fantoni, Massimo;Murri, Rita;Masucci, Luca;Posteraro, Brunella;Sanguinetti, Maurizio;
2015

Abstract

The alterations occurring in the intestinal flora during Clostridium difficile infection (CDI) may promote the translocation of Candida to the blood and the development of candidaemia. The aim of our study was to analyse clinical findings of these patients to determine the risk factors associated with the development of candidaemia subsequent to CDI. We compared 35 patients with candidaemia subsequent to CDI with 105 patients with CDI. Patients with candidaemia showed more severe infections and higher mortality. The ribotype 027 strain and vancomycin treatment at ≥1000 mg/day were prevalent in patients developing candidaemia. CDI may predispose to the translocation of Candida.
Inglese
Russo, A., Falcone, M., Fantoni, M., Murri, R., Masucci, L., Carfagna, P., Ghezzi, M., Posteraro, B., Sanguinetti, M., Venditti, M., Risk factors and clinical outcomes of candidaemia in patients treated for Clostridium difficile infection, <<CLINICAL MICROBIOLOGY AND INFECTION>>, 2015; 21 (5): 493.e1-493.e1-4. [doi:10.1016/j.cmi.2014.12.024] [http://hdl.handle.net/10807/69052]
File in questo prodotto:
File Dimensione Formato  
69052OA.pdf

non disponibili

Tipologia file ?: Versione Editoriale (PDF)
Licenza: Non specificato
Dimensione 169.76 kB
Formato Unknown
169.76 kB Unknown   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/69052
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 24
social impact